本文選題：少弱精子癥 + 十一酸睪酮��； 參考：《新疆醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：觀察十一酸睪酮聯(lián)合左卡尼汀口服溶液治療男性少弱精癥患者的療效。方法：選取我院連續(xù)3次行精液常規(guī)檢查確診為少弱精子癥的患者120例,采用自身前后對(duì)照的臨床研究方法,給予分組后行藥物對(duì)癥治療,分別以精子濃度、精子存活率及精子總活力(PR+NP,%)、配偶妊娠率為主要療效指標(biāo),以PR%精子、精液量評(píng)價(jià)十一酸睪酮聯(lián)合左卡尼汀口服溶液治療男性少弱精子癥的治療效果。結(jié)果：有111例患者完成了臨床研究,同治療前相比,A組患者經(jīng)口服十一酸睪酮治療后,精液濃度及精子存活率較治療前顯著提高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；B組患者經(jīng)口服左卡尼汀口服溶液治療后,精子存活率、精子總活力(PR+NP,%)、PR%精子較治療前顯著提高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；C組患者經(jīng)口服十一酸睪酮聯(lián)合左卡尼汀口服溶液治療后,精液濃度、精子存活率、精子總活力(PR+NP,%)、PR%精子較治療前顯著提高,差異有統(tǒng)計(jì)學(xué)意義(P0.05),A、B、C三組經(jīng)藥物治療后女方妊娠率有明顯差異,C組療效明顯優(yōu)于A組和B組(P0.05),同時(shí),同治療后1月時(shí)相比,C組在精子密度、精子存活率、精子總活力(PR+NP,%)三個(gè)主要參數(shù)于治療后3個(gè)月時(shí)均顯著提高(P0.05),同樣,同治療后2個(gè)月相比,相關(guān)精液參數(shù)在治療后3個(gè)月時(shí)顯著提高(P0.05).結(jié)論：十一酸睪酮聯(lián)合左卡尼汀口服溶液能夠顯著提高少弱精子癥男性精液相關(guān)參數(shù),提高女方妊娠率,且用藥期間未見(jiàn)明顯的不良反應(yīng),可作為臨床醫(yī)師用藥的一種選擇
[Abstract]:Aim: to observe the efficacy of testosterone undecanoate combined with levacarnitine oral solution in the treatment of male oligozoospermia. Methods: 120 cases of oligozoospermia diagnosed by routine semen examination for 3 times in our hospital were selected. Sperm survival rate, total sperm motility and total sperm motility (PR NPN) were used to evaluate the therapeutic effect of testosterone undecanoate combined with L-carnitine oral solution in the treatment of male oligozoospermia. Results: 111 patients completed the clinical study. After oral testosterone undecanoate treatment, semen concentration and sperm survival rate in group A were significantly higher than those before treatment. There was a significant difference in sperm survival rate, total sperm motility and PRN% of patients in group B after oral administration of leucarnitine, which was significantly higher than that before treatment, and there was no significant difference between group B and group B in spermatozoa survival rate and total sperm motility (P < 0.05). There was a significant difference in semen concentration, sperm survival rate and total sperm motility in group C after oral administration of testosterone undecanoate and L-carnitine. There was significant difference in pregnancy rate between group A and group B after drug treatment. The effect of group C was better than that of group A and group B (P 0.05). At the same time, the sperm density and survival rate of group C were higher than those of group C at 1 month after treatment. The three main parameters of total sperm motility (PR NPN) increased significantly at 3 months after treatment. Similarly, compared with 2 months after treatment, the parameters of semen were significantly increased at 3 months after treatment. Conclusion: testosterone undecanoate combined with L-carnitine oral solution can significantly improve the semen parameters and pregnancy rate of oligozoospermia men, and there is no obvious adverse reaction during the treatment. It can be used as a choice for clinicians to use drugs.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R698.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 DimitriosA.Adamopoulos;Medical treatment of idiopathic oligozoospermia and male factor subfertility[J];Asian Journal of Andrology;2000年01期

2 楊瑞鋒,李志艷,徐國(guó)賓,夏鐵安;肉毒堿的生物學(xué)特性及其與臨床疾病的關(guān)系[J];中國(guó)實(shí)驗(yàn)診斷學(xué);2005年02期

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本文編號(hào)：1883820