發(fā)布時(shí)間：2018-05-10 19:22

  本文選題：前列腺癌 + 前列腺增生��； 參考：《新疆醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：研究PEDF和VTN在人前列腺癌組織、良性前列腺增生組織中的表達(dá)情況,探討其表達(dá)與前列腺癌的相關(guān)性及臨床意義。方法：利用免疫組織化學(xué)觀察PEDF和VTN在前列腺癌組織和良性前列腺增生組織中的表達(dá)情況,并對(duì)其結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果：免疫組化顯示PEDF和VTN在前列腺癌組織中的表達(dá)在前列腺癌組和前列腺增生組中的表達(dá)有統(tǒng)計(jì)學(xué)的顯著性意義(P=0.011,P=0.008)。前列腺癌組織中PEDF和VTN表達(dá)在不同年齡無(wú)明顯差異(P=0.345,P=0.434)；前列腺癌組織中PEDF的表達(dá)強(qiáng)度與患者術(shù)前血清PSA、Gleason評(píng)分、臨床分期及腫瘤有無(wú)轉(zhuǎn)移之間存在明顯差異(P0.05)；前列腺癌組織中VTN的表達(dá)強(qiáng)度與患者Gleason評(píng)分、臨床分期及腫瘤有無(wú)轉(zhuǎn)移之間的差異有統(tǒng)計(jì)學(xué)意義(P0.05),而與術(shù)前血清PSA的差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論：1、PEDF和VTN在前列腺癌組中和前列腺增生組的表達(dá)差異具有統(tǒng)計(jì)學(xué)意義,提示通過對(duì)其檢測(cè)可能會(huì)對(duì)前列腺癌的診斷有一定的幫助。2、在前列腺癌中,PEDF的表達(dá)與血清PSA、Gleason評(píng)分、臨床分期及腫瘤有無(wú)轉(zhuǎn)移均有統(tǒng)計(jì)學(xué)意義,提示其在前列腺癌發(fā)生、發(fā)展過程中發(fā)揮重要作用。3、在前列腺癌中,VTN的表達(dá)強(qiáng)度與Gleason評(píng)分、臨床分期及腫瘤有無(wú)轉(zhuǎn)移之間的差異具有統(tǒng)計(jì)學(xué)意義,而與術(shù)前血清PSA的差異無(wú)相關(guān)性。4、PEDF和VTN對(duì)于前列腺癌患者的疾病診斷、病情評(píng)估、療效評(píng)價(jià)以及預(yù)后等方面也可能有指導(dǎo)性的意義。
[Abstract]:Objective: to study the expression of PEDF and VTN in human prostate cancer and benign prostatic hyperplasia (BPH), and to explore the relationship between the expression and the clinical significance. Methods: immunohistochemistry was used to observe the expression of PEDF and VTN in prostate cancer and benign prostatic hyperplasia (BPH), and the results were analyzed statistically. Results: immunohistochemical staining showed that the expression of PEDF and VTN in prostate cancer and prostatic hyperplasia was significantly higher than that in control group. There was no significant difference in the expression of PEDF and VTN in prostate cancer tissues at different ages. The expression of PEDF in prostate cancer tissues was correlated with the preoperative serum PSA-Gleason score. There was significant difference between clinical stage and tumor metastasis (P 0.05). The expression of VTN in prostate cancer tissues and the Gleason score of the patients were significantly different. The difference of clinical stage and tumor metastasis was statistically significant (P 0.05), but there was no significant difference between the clinical stage and preoperative serum PSA. Conclusion the differences between the expression of PEDF and VTN in prostate cancer and prostatic hyperplasia are statistically significant. It is suggested that the detection of PEDF may be helpful in the diagnosis of prostate cancer, and the expression of PEDF in prostate cancer and the serum PSA-Gleason score may be helpful to the diagnosis of prostate cancer. The clinical stage and tumor metastasis were statistically significant, suggesting that they play an important role in the occurrence and development of prostate cancer. The expression intensity of VTN and Gleason score in prostate cancer. The difference of clinical stage and tumor metastasis was statistically significant, but there was no correlation between the difference of serum PSA and preoperative VTN in the diagnosis and evaluation of the disease in patients with prostate cancer. The evaluation of curative effect and prognosis may also have instructive significance.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R737.25

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本文編號(hào)：1870553