本文選題：慢性腎臟病 + 胃泌素��； 參考：《山西醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的 研究血漿胃泌素、胃動素在慢性腎臟病人與正常對照組人群之間有無差異,探討血漿胃泌素、胃動素在慢性腎臟病中的變化規(guī)律。 方法 選慢性腎臟病90例,健康志愿者正常對照組9例,放射免疫法檢測血漿胃泌素、胃動素的含量。對結(jié)果進(jìn)行記錄及統(tǒng)計分析。 結(jié)果 1.慢性腎臟病組血漿胃泌素、胃動素的含量均高于正常對照組(p0.05)。 2.血漿胃泌素含量在慢性腎臟病組的五組(CKD1、CKD2、CKD3、CKD4、CKD5)與正常對照組比較均有顯著性差異(p0.01),且與GFR呈正相關(guān)。 3.血漿胃動素含量在CKD3、CKD4組與正常對照組比較有顯著性差異(p0.01)；在CKD1、CKD2、CKD5組與正常對照組比較無統(tǒng)計學(xué)差異(p0.05),CKD1組、CKD2組、CKD5組、均與GFR呈正相關(guān)；CKD3組、CKD4組與GFR呈負(fù)相關(guān)。 結(jié)論 慢性腎臟病患者血漿胃泌素和胃動素均有變化,其中血漿胃泌素含量隨腎臟疾病的嚴(yán)重程度逐漸升高,血漿胃動素的含量在CKD3、CKD4組高于正常對照組,提示隨著慢性腎臟病程度加重明顯影響消化道分泌和運動功能。
[Abstract]:Purpose To study the difference of plasma gastrin and motilin between patients with chronic kidney and normal control group, and to explore the changes of plasma gastrin and motilin in chronic kidney disease. Method The plasma gastrin and motilin levels were measured by radioimmunoassay in 90 patients with chronic kidney disease and 9 healthy volunteers. Record and analyze the results. Result 1. The plasma levels of gastrin and motilin in chronic kidney disease group were higher than those in normal control group (P 0.05). 2. The plasma gastrin content in the five groups of chronic kidney disease group was significantly different from that in the normal control group (P 0.01) and positively correlated with GFR. 3. The level of plasma motilin in CKD3 / CKD4 group was significantly higher than that in normal control group (p0.01), but there was no significant difference between CKD5 group and normal control group (p 0.05). There was a positive correlation between plasma motilin content and GFR in CKD4 group. Conclusion The plasma levels of gastrin and motilin in patients with chronic kidney disease increased gradually with the severity of renal disease, and the plasma motilin levels in CKD3 / CKD4 group were higher than those in normal control group. The results suggest that with the exacerbation of chronic kidney disease, digestive tract secretion and motor function are significantly affected.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R692.5

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本文編號：1862073