本文選題：血管內(nèi)皮細(xì)胞生長(zhǎng)因子 + 可溶性血管內(nèi)皮細(xì)胞生長(zhǎng)因子受體��； 參考：《中國(guó)實(shí)用內(nèi)科雜志》2016年06期

【摘要】：目的檢測(cè)慢性腎小球腎炎患者血、尿中可溶性血管內(nèi)皮細(xì)胞生長(zhǎng)因子受體1(sFlt-l)的水平,探討sFlt-1在腎臟疾病中的意義。方法以2014年6月至2014年12月中國(guó)醫(yī)科大學(xué)附屬第一醫(yī)院腎內(nèi)科住院的34例腎小球腎炎患者為研究對(duì)象,根據(jù)24 h尿蛋白定量將患者分為非腎病范圍蛋白尿組和腎病范圍蛋白尿組。同時(shí)收集10名健康體檢者作為對(duì)照組。采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測(cè)其血、尿中s Flt-1水平,并分析血、尿sFlt-1與24 h尿蛋白定量的相關(guān)性。結(jié)果對(duì)照組、非腎病范圍蛋白尿組和腎病范圍蛋白尿組患者血sFlt-1分別為(8.61±2.12)μg/L、(32.67±7.06)μg/L、(30.65±8.84)μg/L,尿s Flt-1分別為(6.66±2.37)μg/L、(29.54±5.64)μg/L、(27.41±6.79)μg/L。與對(duì)照組相比,非腎病范圍蛋白尿組和腎病范圍蛋白尿組患者血、尿sFlt-1表達(dá)水平明顯增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);非腎病范圍蛋白尿組和腎病范圍蛋白尿組組間比較,血、尿s Flt-1表達(dá)水平差異無統(tǒng)計(jì)學(xué)意義(P0.05)。血sFlt-1表達(dá)水平與24 h尿蛋白定量無明顯相關(guān)性(r=-0.029,P0.05);尿sFlt-1的表達(dá)與24 h尿蛋白定量無明顯相關(guān)性(r=0.019,P0.05)。結(jié)論 sFlt-1在慢性腎小球腎炎發(fā)生、發(fā)展中發(fā)揮一定作用,檢測(cè)sFlt-1水平并拮抗其生物學(xué)作用在慢性腎小球腎炎的診療中可能具有重要的意義。
[Abstract]:Objective to detect the level of soluble vascular endothelial growth factor receptor (sFlt-1) in blood and urine of patients with chronic glomerulonephritis and to explore the significance of sFlt-1 in renal diseases. Methods from June 2014 to December 2014, 34 patients with glomerulonephritis were enrolled in the Department of Nephrology, the first affiliated Hospital of China Medical University. According to 24 h urinary protein, the patients were divided into non-nephrotic proteinuria group and nephrotic proteinuria group. At the same time, 10 healthy people were collected as the control group. The levels of s Flt-1 in blood and urine were detected by Elisa, and the correlation between blood, urine sFlt-1 and 24 h urine protein was analyzed. Results the serum sFlt-1 of control group, non-nephrotic proteinuria group and nephropathy range proteinuria group were 32.67 鹵7.06 渭 g / L and 30.65 鹵8.84 渭 g / L, respectively, and their urine s Flt-1 were 6.66 鹵2.37 渭 g / L 29.54 鹵5.64 渭 g / L and 27.41 鹵6.79 渭 g / L respectively. Compared with the control group, the expression of sFlt-1 in blood and urine of patients with non-nephrotic proteinuria and nephropathy proteinuria was significantly higher than that of control group (P 0.05), and the blood between non-nephrotic proteinuria group and nephrotic proteinuria group was significantly higher than that of control group, and there was no significant difference between non-nephrotic proteinuria group and nephropathy proteinuria group. There was no significant difference in the expression of s Flt-1 in urine (P 0.05). There was no significant correlation between the expression of sFlt-1 and 24 h urinary protein, but there was no significant correlation between the expression of urinary sFlt-1 and 24 h urine protein. Conclusion sFlt-1 plays a role in the development and development of chronic glomerulonephritis. It may be important to detect the level of sFlt-1 and antagonize its biological effect in the diagnosis and treatment of chronic glomerulonephritis.
【作者單位】： 中國(guó)醫(yī)科大學(xué)附屬第一醫(yī)院腎內(nèi)科;沈陽市紅十字會(huì)醫(yī)院腎內(nèi)科;中國(guó)醫(yī)科大學(xué)附屬盛京醫(yī)院骨外科;
【基金】：遼寧省社會(huì)發(fā)展攻關(guān)計(jì)劃(2012225094) 遼寧省高等學(xué)校優(yōu)秀人才支持計(jì)劃(LJQ2013086) 沈陽市科技計(jì)劃項(xiàng)目(F15-199-1-51)
【分類號(hào)】：R692.31

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