本文選題：男性 + 鋅α糖蛋白�。� 參考：《中華男科學(xué)雜志》2017年11期

【摘要】：目的:了解男性血清鋅α2糖蛋白(ZAG)的水平變化及其與生殖激素的關(guān)系。方法:選取25~65歲體檢男性297例,按血脂水平分為對照組145例和高脂組152例;按年齡分為25~35歲、36~45歲、46~55歲、56~65歲4個年齡組;依據(jù)血清ZAG水平的三分位數(shù)分為3組(Q1,Q2,Q3)。檢測血脂、血糖、ZAG和生殖激素等,比較ZAG與代謝及生殖激素的關(guān)系。結(jié)果:(1)隨著年齡的增長,對照組和病例組男性血清ZAG逐漸下降,在36~45歲和56~65歲明顯下降,有統(tǒng)計學(xué)差異(P0.05)。同年齡組中比較,25~35歲和36~45歲中,高脂組的ZAG水平明顯低于對照組,有統(tǒng)計學(xué)差異(P0.05)。(2)FSH在ZAG低、中、高水平組表達(dá)分別為(7.69±4.07)mIU/ml、(5.65±2.26)mIU/ml和(4.85±1.97)mIU/ml,3組之間比較差異有顯著性(P0.05);T在ZAG低、中、高水平組表達(dá)分別(2.93±1.08)ng/ml、(3.51±1.22)ng/ml和(3.89±1.37)ng/ml,3組之間比較差異有顯著性(P0.05)。(3)男性血清ZAG與年齡、WC、BMI、FBG、TG呈負(fù)相關(guān)(r=-0.58,-0.21,-0.22,-0.16,-0.27,P均0.05);與TT呈正相關(guān)(r=0.36,P0.05);年齡、BMI和TG是ZAG的獨立影響因素。結(jié)論:男性血清鋅α2糖蛋白隨增齡而下降,與脂質(zhì)代謝和腹型肥胖有關(guān),并且其水平的變化和男性生殖激素有關(guān)。
[Abstract]:Objective: to investigate the changes of serum zinc 偽 2 glycoprotein (ZAGG) levels and their relationship with reproductive hormones in men. Methods: 297 healthy males aged 25 ~ 65 years were divided into control group (n = 145) and hyperlipidemia group (n = 152) according to the level of serum lipids, 4 age groups (25 ~ 35 years old, 46 ~ 55 years old, 56 ~ 65 years old), and 3 groups were divided into 3 groups according to the three-digit number of serum ZAG level. Blood lipids, blood glucose Zag and reproductive hormones were measured to compare the relationship between ZAG and metabolism and reproductive hormones. Results (1) with the increase of age, the serum ZAG decreased gradually in the control group and the case group, and decreased significantly at the age of 36 ~ 45 years and 56 ~ 65 years old (P < 0.05). In the same age group, the level of ZAG in the high-fat group was significantly lower than that in the control group (P 0.05, P < 0.05). The expression of ZAG in the high group was 7.69 鹵4.07 mIUU / ml 5.65 鹵2.26)mIU/ml and 4.85 鹵1.97 mm / ml respectively. There was a significant difference between the three groups. There were significant differences in the expression of serum ZAG between high level group (2.93 鹵1.08ng / ml) 3.51 鹵1.22)ng/ml and 3.89 鹵1.37ngml / ml group (P < 0.05). There was a negative correlation between serum ZAG and TG of age group (r -0.58- 0.21- 0.22ng-1 -0.22ng / ml -0.22ng-1) -0.16ng-1 / 0.27P; there was a positive correlation between serum ZAG and TT (0.36ngml); age and TG were independent influencing factors of ZAG. Conclusion: the serum zinc 偽 2 glycoprotein decreased with age, which was related to lipid metabolism and abdominal obesity, and the change of serum zinc 偽 2 glycoprotein level was related to male reproductive hormone.
【作者單位】： 河北省人民醫(yī)院檢驗科;河北省計劃生育科學(xué)技術(shù)研究院(國家衛(wèi)計委計劃生育與優(yōu)生重點實驗室);
【基金】：河北省科技計劃(163977122D)~~
【分類號】：R698.2

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