本文選題：血壓變異性 + 血管鈣化�。� 參考：《中國現(xiàn)代醫(yī)學雜志》2017年27期

【摘要】：目的探討尿毒癥患者血管鈣化與血壓變異性的相關性。方法收集患者的一般資料,利用24 h動態(tài)血壓儀檢測脈壓、血壓變異系數(shù)及晝夜節(jié)律變化,利用雙源螺旋CT對心臟平掃,計算冠狀動脈(冠脈)鈣化評分,分析冠脈鈣化評分與血壓變異的相關性。結果 72例尿毒癥患者,冠脈鈣化陽性組與陰性組相比,24 h脈壓、日間脈壓、夜間脈壓、獨立于夜間收縮壓的變異系數(shù)及獨立于夜間舒張壓的變異系數(shù)升高,差異有統(tǒng)計學意義(P0.05);按冠脈鈣化評分分組,中度鈣化組與陰性組比較,24 h脈壓、日間脈壓及夜間脈壓升高,差異有統(tǒng)計學意義性(P0.05)。相關性分析顯示,冠脈鈣化評分與24 h收縮壓變異系數(shù)(r=0.468,P=0.028)、夜間收縮壓變異系數(shù)(r=0.641,P=0.001)、獨立于24 h收縮壓的變異系數(shù)(r=0.540,P=0.009)及獨立于夜間收縮壓的變異系數(shù)(r=0.756,P=0.000)均正相關。結論尿毒癥患者冠脈鈣化陽性組的脈壓及夜間血壓變異系數(shù)高于陰性組;尿毒癥患者冠脈鈣化評分與收縮壓變異系數(shù)正相關。
[Abstract]:Objective to investigate the relationship between vascular calcification and blood pressure variability in uremic patients. Methods the general data of the patients were collected. Pulse pressure, blood pressure variation coefficient and circadian rhythm were measured by 24 h ambulatory blood pressure meter. The coronary artery (coronary artery) calcification score was calculated by double source spiral CT scan. To analyze the correlation between coronary artery calcification score and blood pressure variation. Results in 72 patients with uremia, 24 h pulse pressure, day pulse pressure, nocturnal pulse pressure, coefficient of variation independent of nocturnal systolic blood pressure and coefficient of variation independent of night diastolic blood pressure were increased in positive coronary artery calcification group compared with negative group. According to the coronary artery calcification score, the moderate calcification group was compared with the negative group in 24 h pulse pressure, day pulse pressure and nocturnal pulse pressure, the difference was statistically significant (P 0.05). Correlation analysis showed that the coronary artery calcification score was positively correlated with the coefficient of variation of systolic blood pressure at 24 h (r = 0.468), the coefficient of variation of systolic blood pressure at night (r = 0.641), the coefficient of variation independent of 24 h (r = 0.540) and the coefficient of variation independent of nocturnal systolic pressure (r = 0.756P ~ (0.000). Conclusion the coefficient of variation of pulse pressure and nocturnal blood pressure in uremic patients with positive coronary artery calcification is higher than that in negative group, and the coronary artery calcification score is positively correlated with systolic blood pressure coefficient of variation in uremic patients.
【作者單位】： 大連醫(yī)科大學附屬第一醫(yī)院(遼寧省轉化醫(yī)學中心)腎內(nèi)科;大連醫(yī)科大學附屬第一醫(yī)院(遼寧省轉化醫(yī)學中心)心臟CT檢查科;
【基金】：大連市優(yōu)秀青年科技人才基金(No:2008J23JH036)
【分類號】：R692.5

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