本文選題：造血干細(xì)胞移植術(shù) + 出血性膀胱炎��； 參考：《浙江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的造血干細(xì)胞移植已成為治療惡性血液病的有效手段,也是治愈某些血液病的唯一方法。而造血干細(xì)胞移植術(shù)后并發(fā)出血性膀胱炎的發(fā)病率較高,影響了患者的生存率。研究探討造血干細(xì)胞移植術(shù)后并發(fā)出血性膀胱炎的危險因素,從而為預(yù)測出血性膀胱炎出現(xiàn)各種不良事件的可能性提供參考。方法對2014年6月-2016年10月在寧波市鄞州人民醫(yī)院確診血液系統(tǒng)惡性腫瘤并進(jìn)行造血干細(xì)胞治療的100例患者的臨床資料進(jìn)行回顧性分析。通過單因素和多因素Logistic回歸分析篩選出與造血干細(xì)胞移植術(shù)后并發(fā)血性膀胱炎相關(guān)的危險因素;比較出血性膀胱炎組與非出血性膀胱炎組在年齡、性別、疾病類型、移植類型、預(yù)處理藥物、預(yù)防GVHD的藥物種類、CMV感染、BK病毒尿、aGVHD9個方面的差別。研究造血干細(xì)胞移植術(shù)后并發(fā)出血性膀胱炎的相關(guān)危險因素。結(jié)果造血干細(xì)胞移植與出血性膀胱炎發(fā)病情況:100例患者成功植入100例,其中有22例發(fā)生出血性膀胱炎發(fā)病率為22%。男性15例,女性7例。單因素分析表明,其中有3個危險因素與出血性膀胱炎的發(fā)生密切相關(guān):(1)移植類型(X2=100.000;P0.001)(2)CMV 感染(X2=5.288;P=0.021)(3)BK病毒尿(X2=23.310;P0.001)。然后對上述中有統(tǒng)計學(xué)意義(P0.05)的危險因素進(jìn)行Logistic多因素回歸分析,只有BK病毒尿為出血性膀胱炎的危險因素(P0.05,OR=4.758)。在其他因素不變的情況下,患有BK病毒尿的人發(fā)生出血性膀胱炎的可能性是未患BK病毒尿的4.758倍。結(jié)論出血性膀胱炎是造血干細(xì)胞移植后的重要并發(fā)癥,BK病毒尿是發(fā)生出血性膀胱炎的獨立因素,危險性顯著增加。
[Abstract]:Objective Hematopoietic stem cell transplantation (HSCT) has become an effective method for the treatment of malignant hematological diseases and the only way to cure some hematological diseases. The incidence of hemorrhagic cystitis after hematopoietic stem cell transplantation was high, which affected the survival rate of patients. To investigate the risk factors of haemorrhagic cystitis after hematopoietic stem cell transplantation (HSCT), and to provide a reference for predicting the occurrence of various adverse events in hemorrhagic cystitis. Methods the clinical data of 100 patients with hematopoietic stem cell therapy in Yinzhou people's Hospital of Ningbo City from June 2014 to October 2016 were analyzed retrospectively. The risk factors associated with hematopoietic cystitis after hematopoietic stem cell transplantation were screened by univariate and multivariate Logistic regression analysis, and the age, sex, disease type and transplant type were compared between hemorrhagic cystitis group and non-hemorrhagic cystitis group. Pretreatment of drugs to prevent GVHD from infecting BK virus in urine (AGV HD 9). To study the risk factors of hemorrhagic cystitis after hematopoietic stem cell transplantation. Results 100 cases of hematopoietic stem cell transplantation and hemorrhagic cystitis were successfully implanted in 100 cases, of which 22 cases developed hemorrhagic cystitis. There were 15 males and 7 females. Univariate analysis showed that three risk factors were closely related to the occurrence of hemorrhagic cystitis. The Logistic multivariate regression analysis showed that only BK virus urine was the risk factor of hemorrhagic cystitis. People with BK virus urine were 4.758 times more likely to develop hemorrhagic cystitis than those without BK virus urine, other factors being equal. Conclusion hemorrhagic cystitis is an important complication after hematopoietic stem cell transplantation.
【學(xué)位授予單位】：浙江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R733;R694.3

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