本文選題：維吾爾族 + IgA腎病��； 參考：《石河子大學(xué)》2014年碩士論文

【摘要】：目的：探討血尿酸水平與維吾爾族IgA腎病（IgAN）臨床及病理嚴(yán)重程度的關(guān)聯(lián)性，進(jìn)一步分析維吾爾族IgAN伴高尿酸血癥的影響因素。 方法：隨機(jī)選取2012年1月-2013年6月在新疆維吾爾族自治區(qū)人民醫(yī)院經(jīng)腎活檢確診為原發(fā)性IgA腎病維吾爾族患者99例，收集所有納入研究對(duì)象的臨床資料（性別、年齡、體重指數(shù)、高血壓病史、血壓、血尿酸、腎功能、尿素氮、膽固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、尿尿酸、尿肌酐、24h尿蛋白定量）及病理資料。依據(jù)血尿酸水平，分為高尿酸血癥組和正常血尿酸組，回顧性分析兩組臨床及病理資料，選用線性相關(guān)來分析腎臟病理損傷的影響因素；應(yīng)用多元線性回歸法分析IgA腎病患合并高尿酸血癥的危險(xiǎn)因素。 結(jié)果：維吾爾族IgA腎病患者中高血尿酸癥的發(fā)生率為17.17%；與血尿酸正常組相比，高尿酸血癥組的體重指數(shù)（BMI）、收縮壓、血糖、血肌酐、尿素氮、總膽固醇、甘油三酯、低密度脂蛋白、脂蛋白、24小時(shí)尿蛋白定量明顯高于血尿酸正常組，腎小球?yàn)V過率低于血尿酸正常組（P0.05)；高尿酸血癥組的病理Lee氏分級(jí)較嚴(yán)重，腎小球損傷程度較重，血尿酸上升到360mmol/L以上水平，腎間質(zhì)質(zhì)纖維化的發(fā)生率顯著升高；Spearman相關(guān)分析結(jié)果顯示：血尿酸、肌酐、24h尿蛋白定量均與腎小球損傷嚴(yán)重程度呈正相關(guān)，與腎小球硬化和血管壁病變相關(guān)性最強(qiáng)的為血肌酐，，與新月體的形成相關(guān)性最強(qiáng)的為血尿酸；多元線性回歸分析表明：BMI、男性、血管壁病變、甘油三酯、血肌酐是維吾爾族IgA腎病患者伴發(fā)高尿酸血癥獨(dú)立危險(xiǎn)因素。 結(jié)論：維吾爾族IgA腎病合并高尿酸血癥的患者臨床和病理損傷程度重于IgA腎病血尿酸正常的患者，高尿酸血癥可能參與維吾爾族IgA腎病的進(jìn)展。
[Abstract]:Objective: to investigate the relationship between serum uric acid level and clinical and pathological severity of IgA nephropathy in Uygur nationality, and to analyze the influencing factors of IgAN with hyperuricemia in Uygur nationality. Methods: 99 Uygur patients with primary IgA nephropathy diagnosed by renal biopsy from January 2012 to June 2013 in Xinjiang Uygur Autonomous region people's Hospital were randomly selected, and all the clinical data (sex, age, age) were collected. Body mass index, history of hypertension, blood pressure, uric acid, renal function, urea nitrogen, cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, uric acid, urinary creatinine 24 hours urinary protein quantitative and pathological data. According to the level of serum uric acid, it was divided into hyperuricemia group and normal blood uric acid group. The clinical and pathological data of the two groups were analyzed retrospectively, and the influencing factors of renal pathological injury were analyzed by linear correlation. Multivariate linear regression method was used to analyze the risk factors of IgA nephropathy complicated with hyperuricemia. Results: the incidence of hyperuricemia in Uygur patients with IgA nephropathy was 17.17.The body mass index (BMI), systolic blood pressure (SBP), blood glucose, creatinine, urea nitrogen, total cholesterol, triglyceride in hyperuricemia group were higher than those in normal group. The 24 hour urinary protein quantification of low density lipoprotein and lipoprotein was significantly higher than that of normal serum uric acid group, and the glomerular filtration rate was lower than that of normal serum uric acid group (P 0.05), the pathological Lee's grade of hyperuricemia group was more serious, and the degree of glomerular injury was more serious. The incidence of renal interstitial fibrosis was significantly increased. The results of Spearman correlation analysis showed that serum uric acid and creatinine 24 hours urinary protein were positively correlated with the severity of glomerular injury. The strongest correlation with glomerulosclerosis and vascular wall lesions was serum creatinine, and the strongest correlation with the formation of crescents was serum uric acid. Multivariate linear regression analysis showed that: BMI, male, vascular wall lesion, triglyceride, Serum creatinine is an independent risk factor of hyperuricemia in Uygur patients with IgA nephropathy. Conclusion: the degree of clinical and pathological damage in Uygur patients with IgA nephropathy complicated with hyperuricemia is more serious than that in IgA nephropathy patients with normal serum uric acid. Hyperuricemia may be involved in the progression of Uygur IgA nephropathy.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R692.31

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 范軍芬;張史昭;魯科達(dá);陳q

本文編號(hào)：1798501