本文選題：前列腺素E + 膿毒癥��； 參考：《中國(guó)老年學(xué)雜志》2017年24期

【摘要】：目的探討不同劑量前列腺素E治療膿毒癥致急性腎損傷患者的療效及安全性。方法對(duì)86例膿毒癥致急性腎損傷患者以數(shù)字法隨機(jī)分成觀察組(43例)和對(duì)照組(43例)。對(duì)照組給予低劑量前列腺素E,觀察組給予高劑量前列腺素E,分析不同劑量對(duì)患者療效、炎癥因子、腎功能的影響。結(jié)果觀察組治療后總有效率為83.72%(36/43)顯著高于對(duì)照組[62.79%(27/43),P0.05]。治療前兩組白細(xì)胞介素(IL)-10及IL-6和腫瘤壞死因子(TNF)-α差異均不顯著(P0.05),治療后觀察組IL-10及IL-6和TNF-α水平均顯著低于對(duì)照組(均P0.05);治療前兩組尿素氮(BUN)、血肌酐(SCr)水平差異均不顯著,治療后3 d及7 d觀察組BUN、SCr水平均顯著低于對(duì)照組(均P0.05);治療前兩組尿N-乙酰-β-D-葡萄糖苷酶(NAG),γ-谷氨酰轉(zhuǎn)肽酶(γ-GTP),α1-微球蛋白(MG)無(wú)顯著差異(P0.05),治療后觀察組尿NAG、γ-GTP、α1-MG均顯著低于對(duì)照組(均P0.05)。結(jié)論相較于低劑量靜脈滴注前列腺素E,高劑量療效更加顯著,還能顯著降低體內(nèi)炎癥因子,改善患者腎功能。
[Abstract]:Objective to evaluate the efficacy and safety of prostaglandin E (PGE) in the treatment of acute renal injury caused by sepsis. Methods 86 patients with acute renal injury caused by sepsis were randomly divided into observation group (n = 43) and control group (n = 43). The control group was given low dose prostaglandin E, the observation group was given high dose prostaglandin E, and the effects of different doses on the curative effect, inflammatory factor and renal function were analyzed. Results the total effective rate of the observation group after treatment was 83.72% 36 / 43), which was significantly higher than that of the control group [62.79% 27 / 43 P 0.05]. Before treatment, there was no significant difference in IL-10, IL-6 and TNF- 偽 between the two groups. The levels of IL-10, IL-6 and TNF- 偽 in the observation group were significantly lower than those in the control group after treatment (all P 0.05), and the levels of bun bun and creatinine in the two groups were not significantly different before treatment. 3 and 7 days after treatment, the level of bun SCr in the observation group was significantly lower than that in the control group (all P 0.05), and there was no significant difference between the two groups in urine naga, 緯 -glutamyl transpeptidase (緯 -GTPN) and 緯 -glutamyl transpeptidase (偽 1-microglobulin) before and after treatment (P0.05). After treatment, the urine NAGG, 緯 -TP-GG and 偽 1-MG in the observation group were significantly lower than those in the control group (P < 0.05). It was lower than the control group (P 0.05). Conclusion compared with low dose intravenous infusion of prostaglandin E, high dose prostaglandin E can significantly reduce inflammatory factors and improve renal function.
【作者單位】： 勝利油田中心醫(yī)院重癥醫(yī)學(xué)科;
【分類號(hào)】：R459.7;R692.5

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