本文選題：肥胖 + 肥胖相關性腎小球病��； 參考：《首都醫(yī)科大學》2017年碩士論文

【摘要】：目的血清分泌型α-klotho蛋白參與能量代謝調節(jié),但其水平與肥胖相關腎小球病(obesity-related glomerulonepathy,ORG)間關系未見報道。本研究檢測不同肥胖人群的血清α-klotho蛋白水平,探討其與肥胖相關性腎小球病(ORG)發(fā)病之間的相關關系。方法選取經腎穿刺病理檢查確診為ORG的患者48例,以及性別、年齡、體質指數與之匹配的單純性肥胖患者及肥胖慢性腎臟病(CKD)患者各48例,分別收集他們的臨床資料和檢驗指標,并采用酶聯(lián)免疫吸附測定法(ELISA)檢測血清α-klotho蛋白濃度。結果單因素組間比較顯示,ORG組的血清α-klotho蛋白水平中位數為572.66(439.92,690.58)pg/ml,顯著低于單純性肥胖組中位數值635.85(559.52,769.20)pg/ml和肥胖CKD組中位數值690.30(516.15,828.20)pg/ml(P0.01)。多分類多因素Logistic回歸分析顯示,血清α-klotho蛋白與ORG的發(fā)病獨立相關,ORG組分別與單純性肥胖組和肥胖CKD組相比,血清α-klotho蛋白每增加100pg/ml,ORG的發(fā)病風險各降低35%(OR值:0.652,95%可信區(qū)間:0.487~0.872)和38%(OR值:0.617,95%可信區(qū)間:0.453~0.832)。結論血清α-klotho蛋白水平在ORG患者中顯著降低,與ORG的發(fā)病獨立相關,α-klotho可能是拮抗ORG發(fā)病的保護因子。
[Abstract]:Objective Serum secretory 偽 -klotho protein is involved in the regulation of energy metabolism, but the relationship between the level of 偽 -klotho protein and obesity-related glomerulonephritis (ORG) has not been reported. In this study, the serum 偽 -klotho protein levels were measured in different obese subjects, and the correlation between 偽 -klotho protein and the incidence of obesity associated glomerulonephritis (ORG) was investigated. Methods 48 patients with ORG diagnosed by renal biopsy, 48 patients with simple obesity matched by sex, age and BMI, and 48 patients with obese chronic kidney disease were selected. Their clinical data and test indexes were collected, and the serum 偽 -klotho protein concentration was detected by enzyme linked immunosorbent assay (Elisa). Results the median level of serum 偽 -klotho protein in ORG group was 572.66 ~ 439.92690.58 g / ml, which was significantly lower than that in simple obesity group (635.85(559.52769.20)pg/ml) and obese CKD group (690.30) 516.15828.20 渭 g / ml / ml P0.01. Results the median level of 偽 -klotho protein in ORG group was 572.66 ~ 439.92690.58 g / ml, which was significantly lower than that in simple obesity group and obese CKD group. Multivariate Logistic regression analysis showed that serum 偽 -klotho protein was correlated with the incidence of ORG in ORG group, compared with simple obesity group and obese CKD group, respectively. The risk of 偽 -klotho protein increased by 100pg / ml ORG decreased the 35%(OR value of 0: 0. 652% 95% confidence interval: 0. 487% 0. 872%) and the 38%(OR value of 0. 617% 95% confidence interval: 0. 453% 0. 832%. Conclusion the level of serum 偽 -klotho protein is significantly lower in patients with ORG, which is independent of the pathogenesis of ORG. 偽 -klotho may be a protective factor against the pathogenesis of ORG.
【學位授予單位】：首都醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R692.6

【參考文獻】

相關期刊論文 前10條

1 劉彬彬;王琦琦;于石成;胡躍華;么鴻雁;孫謹芳;譚云洪;;二項分類logistic回歸的基本原理和關鍵問題[J];中國防癆雜志;2016年08期

2 拜霖楠;程虹;楊敏;芮宏亮;董靖;諶貽璞;;α-klotho蛋白拮抗瘦素損傷小鼠足細胞的實驗研究[J];中國中西醫(yī)結合腎病雜志;2016年07期

3 楊敏;王國勤;芮宏亮;裴源源;程虹;諶貽璞;;α-klotho蛋白與肥胖相關腎小球病的相關研究[J];中華腎臟病雜志;2015年02期

4 裴源源;楊敏;芮宏亮;王艷艷;董鴻瑞;程虹;諶貽璞;;肥胖相關性腎小球病小鼠模型的建立[J];中國中西醫(yī)結合腎病雜志;2014年02期

5 譚敏;諶貽璞;唐功耀;芮宏亮;;脂聯(lián)素拮抗血管緊張素Ⅱ誘導系膜細胞細胞外基質產生[J];中華腎臟病雜志;2011年08期

6 徐楊;程虹;諶貽璞;鄒古明;董鴻瑞;;代謝綜合征對IgA腎病患者病情的影響[J];中華腎臟病雜志;2010年08期

7 程虹;諶貽璞;;代謝綜合征腎損害診治新進展[J];北京醫(yī)學;2010年04期

8 呂曉珍;詹思延;;第四講:病例對照研究[J];中國循證兒科雜志;2009年05期

9 程虹;諶貽璞;張聰;方靜;董鴻瑞;李文歌;鄒萬忠;;兩種肥胖相關性腎小球病臨床病理特點的比較[J];中華腎臟病雜志;2009年04期

10 程虹;諶貽璞;;肥胖相關性腎小球病研究進展[J];中國實用內科雜志;2007年01期

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