本文選題：造影劑 + 造影劑腎病��； 參考：《福建醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的比較使用低滲與等滲對(duì)比劑對(duì)接受行冠狀動(dòng)脈造影及介入治療的75歲以上老年患者的腎臟功能的影響。 方法回顧性分析2011年1月至2013年12月于廈門(mén)市心臟中心心血管內(nèi)科住院行冠狀動(dòng)脈造影及介入治療的75歲以上老年患者202例的資料，著重比較低滲與等滲對(duì)比劑對(duì)患者腎臟功能的影響。根據(jù)使用的造影劑類(lèi)型不同，將患者分為A組(低滲造影劑組-LOCM，碘普羅胺)98例和B組(等滲造影劑組-IOCM，碘克沙醇)104例，，比較兩組患者的臨床特點(diǎn)、冠脈介入術(shù)前后血清肌酐(Scr)及估算腎小球?yàn)V過(guò)率（eGFR）變化、造影劑腎病(CIN)的發(fā)生率情況。 結(jié)果兩組患者在臨床特點(diǎn)、手術(shù)前后血清肌酐水平、估算腎小球?yàn)V過(guò)率水平及估算腎小球?yàn)V過(guò)率差值的均值比較，差異均無(wú)統(tǒng)計(jì)學(xué)意義（P0.05）；使用兩種不同類(lèi)型造影劑均可能引起Scr的增高及eGFR的下降，導(dǎo)致CIN的發(fā)生，該202例患者中有5例發(fā)生CIN（總發(fā)生率為2.48％），其中A組4例，B組1例，低滲造影劑組的CIN發(fā)生率高于等滲造影劑組(4.08％VS0.96％)，但兩組CIN發(fā)生率差異卻無(wú)統(tǒng)計(jì)學(xué)意義（P0.05）。 結(jié)論對(duì)于75歲以上老年人行冠脈介入手術(shù)時(shí)，使用低滲和等滲對(duì)比劑對(duì)術(shù)后短期腎功能的影響作用相當(dāng)，尚不能認(rèn)為等滲造影劑對(duì)腎功能的影響優(yōu)于低滲造影劑。
[Abstract]:Objective to compare the effects of hypotonic and isosmotic contrast media on renal function in patients over 75 years of age undergoing coronary angiography and interventional therapy. Methods 202 patients over 75 years old who were hospitalized in Department of Cardiovascular Medicine of Xiamen Heart Center from January 2011 to December 2013 were analyzed retrospectively. The effects of hypotonic and isosmotic contrast agents on renal function were compared. According to the types of contrast agents used, the patients were divided into two groups: group A (hypotonic contrast agent group -LOCM), iopramide group (98 cases) and group B (isosmotic contrast agent group -IOCM-104 cases). The clinical characteristics of the two groups were compared. Before and after coronary intervention, the changes of serum creatinine (SCR), the estimation of glomerular filtration rate (GFR) and the incidence of contrast agent nephropathy (CINs) were observed. Results the clinical characteristics, serum creatinine level, estimated glomerular filtration rate and the mean value of the difference between the two groups were compared. The difference was not statistically significant (P 0.05), the increase of Scr and the decrease of eGFR might be caused by the use of two kinds of contrast agents, and the occurrence of CIN was found in 5 cases (the total incidence rate was 2.48%), and 1 case in group A (4 cases) and group B (1 case). The incidence of CIN in the hypotonic contrast group was higher than that in the isosmotic contrast medium group (4.08 vs 0.96), but there was no significant difference in the incidence of CIN between the two groups (P 0.05). Conclusion the effects of hypotonic contrast agent and isosmotic contrast agent on renal function in patients over 75 years of age after coronary intervention are equal, and the effect of isosmotic contrast agent on renal function is not superior to that of hypotonic contrast agent.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R692

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 鄭偉;那宇;袁洪萍;;肝臟型脂肪酸結(jié)合蛋白與慢性腎臟病的相關(guān)性研究[J];中國(guó)實(shí)驗(yàn)診斷學(xué);2011年05期

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