本文選題：LifePort腎臟轉(zhuǎn)運器 + 移植腎功能延遲恢復(fù)��； 參考：《吉林大學(xué)》2014年碩士論文

【摘要】：目的：討論LifePort在DCD供腎腎移植中應(yīng)用的有效性，總結(jié)LifePort的使用經(jīng)驗。 方法：吉林大學(xué)第一醫(yī)院2012年8月至2013年6月實施DCD13例（共26個DCD供腎移植），每例DCD供者的一個腎臟隨機采用傳統(tǒng)冰桶冷藏保存，共13例（傳統(tǒng)冰桶組）；另一個腎臟使用LifePort低溫機器灌注保存，共13例（LifePort組）。對比分析二組在腎移植術(shù)后的早期移植效果。 結(jié)果：26個DCD供腎移植手術(shù)均獲得成功，，術(shù)后發(fā)生DGF4例，發(fā)生率（15.3%，4/26），其中LifePort組1例（7.6%，1/13），傳統(tǒng)冰桶組3例（23.0%，3/13），LifePort組DGF發(fā)生率顯著低于傳統(tǒng)冰桶組（p0.05），4例發(fā)生DGF受者移植腎功能在術(shù)后20~45天恢復(fù)正常。未發(fā)生DGF的病例資料，術(shù)后第7天的平均血清肌酐（Scr）值，其中LifePort組93.61±25.05umol/L，傳統(tǒng)冰桶組106.79±34.27umol/L，兩組比較無顯著差異（P0.05）；LifePort組移植腎血清肌酐恢復(fù)正常平均時間5.39±0.97天，傳統(tǒng)冰桶組移植腎血清肌酐恢復(fù)正常平均時間15.38±3.9天，兩組比較差異具有顯著性（p0.05）。圍手術(shù)期發(fā)生急性排斥反應(yīng)2例，發(fā)生率（7.6%，2/26）其中LifePort組1例（7.6%，1/13），傳統(tǒng)冰桶組1例（7.60%，1/13），兩組急性排斥反應(yīng)發(fā)生率比較無顯著性差異（P0.05），經(jīng)治療后均逆轉(zhuǎn)。 結(jié)論：應(yīng)用LifePort保存DCD供腎能縮短移植腎臟功能恢復(fù)的時間，可以顯著降低腎移植后DGF的發(fā)生率。應(yīng)用LifePort保存DCD供腎安全可靠。
[Abstract]:Objective: to discuss the effectiveness of LifePort in DCD donor kidney transplantation and summarize the experience of LifePort.Methods: DCD13 was performed in the first Hospital of Jilin University from August 2012 to June 2013 (26 cases of DCD donor kidney transplantation). One kidney of each DCD donor was stored in a traditional ice bucket at random.A total of 13 cases (traditional ice bucket group) and another kidney (13 cases of LifePort group) were perfused with LifePort cryogenic machine.The effects of early transplantation after renal transplantation in two groups were compared and analyzed.Results: all 26 DCD donor kidney transplantation operations were successful, and DGF4 occurred in all cases.The incidence of DGF in the LifePort group was significantly lower than that in the conventional ice bucket group. The incidence of DGF in the traditional ice bucket group was significantly lower than that in the conventional ice bucket group. The incidence of DGF in the traditional ice bucket group was significantly lower than that in the conventional ice bucket group. The renal graft function of 4 DGF recipients recovered to normal 20 45 days after operation.There was no significant difference between the two groups in the mean creatinine creatinine (creatinine) on the 7th day after operation, in the LifePort group (93.61 鹵25.05 umol/ L) and the traditional ice bucket group (106.79 鹵34.27 umol/ L). There was no significant difference between the two groups in the mean time of serum creatinine recovery to normal in the P0.05-LifePort group (5.39 鹵0.97 days).The mean time of serum creatinine recovery in the traditional ice bucket group was 15.38 鹵3.9 days, and the difference between the two groups was significant (P 0.05).There were 2 cases of acute rejection in perioperative period, the incidence of acute rejection was 7.6 / 26) among them, one case in LifePort group was 1 / 13 in LifePort group, and one case in traditional ice bucket group. There was no significant difference in the incidence of acute rejection between the two groups (P 0.05), all of which were reversed after treatment.Conclusion: preservation of DCD donor kidney with LifePort can shorten the time of renal function recovery, and can significantly reduce the incidence of DGF after renal transplantation.Using LifePort to preserve DCD donor kidney is safe and reliable.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R699.2

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相關(guān)期刊論文 前1條

1 陳忠華;;人類器官移植供體來源的發(fā)展歷程[J];中華移植雜志(電子版);2009年04期

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