本文選題：狼瘡性腎炎 + CXCL�。� 參考：《安徽醫(yī)科大學(xué)學(xué)報(bào)》2014年04期

【摘要】：目的探討趨化因子配體16(CXCL16)及趨化因子配體10(CXCL10)在狼瘡性腎炎(LN)患者血清、尿液以及腎臟內(nèi)的表達(dá)以及與疾病活動(dòng)的關(guān)系。方法 ELISA法檢測(cè)LN患者及正常對(duì)照者血清、尿液中CXCL16、CXCL10的表達(dá)水平,免疫組化法檢測(cè)經(jīng)腎臟活檢確診為L(zhǎng)N的患者以及正常對(duì)照者腎臟組織中的CXCL16的表達(dá)水平。結(jié)果 LN患者血清以及尿液中的CXCL16、CXCL10與正常對(duì)照者比較均升高(P0.01),且血清中CXCL10水平與系統(tǒng)性紅斑狼瘡疾病活動(dòng)指數(shù)(SLEDAI)評(píng)分呈正相關(guān)(r=0.39,P0.01),與補(bǔ)體C3呈負(fù)相關(guān)(r=-0.49,P0.01),尿液中CXCL16水平與SLEDAI評(píng)分呈正相關(guān)(r=0.34,P0.05)。正常對(duì)照組腎臟的小管上皮細(xì)胞可見(jiàn)CXCL16較強(qiáng)的表達(dá),腎小球很少表達(dá),但在LN患者可見(jiàn)小管中表達(dá)有所增強(qiáng),小球中明顯增強(qiáng),其腎內(nèi)的CXCL16的表達(dá)水平較正常對(duì)照組上升(P0.05),尤以Ⅳ型顯著(P0.05)。結(jié)論 CXCL10、CXCL16可能參與LN的發(fā)病過(guò)程,血清CXCL10和尿液中CXCL16水平的檢測(cè)對(duì)于判斷疾病的臨床活動(dòng)具有一定的意義,其中CXCL16可能與LN的病理變化有關(guān)。
[Abstract]:Objective to investigate the expression of chemokine ligand 16 (CXCL16) and chemokine ligand 10 (CXCL10) in serum, urine and kidney of patients with lupus nephritis and its relationship with disease activity.Methods the expression of CXCL16CXCL10 in serum and urine of LN patients and normal controls was detected by ELISA method, and the expression of CXCL16 in renal tissues of LN patients diagnosed by renal biopsy and normal controls was detected by immunohistochemistry.Results the serum and urine levels of CXCL16CXCL10 in LN patients were significantly higher than those in normal controls (P 0.01). The serum CXCL10 level was positively correlated with the SLEDAI score of systemic lupus erythematosus disease activity index (SLEDAI), negatively correlated with complement C3, r-0.49P0.01a, and CXCL16 water in urine.There was a positive correlation between flat and SLEDAI score.In normal control group, there was a strong expression of CXCL16 in the epithelial cells of renal tubules, which was rarely expressed in glomeruli, but increased in tubules and glomeruli in LN patients.The expression of CXCL16 in the kidney was higher than that in the normal control group, especially in type 鈪，

本文編號(hào)：1753064