發(fā)布時(shí)間：2018-04-10 17:48

  本文選題：IgA腎病 + 系膜區(qū)IgG沉積�。� 參考：《南方醫(yī)科大學(xué)學(xué)報(bào)》2017年03期

【摘要】：目的探討IgA腎病患者伴系膜區(qū)IgG沉積與單純IgA沉積間臨床及病理之間的關(guān)系。方法收集自2009年11月~2016年2月于南方醫(yī)科大學(xué)第三附屬醫(yī)院腎活檢診斷為IgA腎病患者122例。所有腎活檢樣本均行光鏡、免疫熒光和電鏡檢查。根據(jù)患者免疫熒光結(jié)果系膜區(qū)有無(wú)IgG沉積,將IgA腎病患者分為單純IgA沉積組(n=63)與IgA-IgG沉積組(n=59)。對(duì)所有患者進(jìn)行Lee分級(jí)及牛津分級(jí)。對(duì)比兩組臨床及病理差異。結(jié)果 IgA腎病伴IgG沉積組臨床血肌酐、24小時(shí)尿蛋白、血尿酸、甘油三酯水平均高于單純IgA沉積組(P0.05);eGFR低于單純IgA沉積組(P0.001);病理中有更多的患者處于Lee氏分級(jí)IV-V級(jí)、腎小管萎縮或/和間質(zhì)纖維化評(píng)分及MEST評(píng)分≥3比例多(P0.05)。結(jié)論 IgA腎病系膜區(qū)伴IgG沉積患者臨床及病理較重,應(yīng)加強(qiáng)對(duì)IgA腎病系膜區(qū)伴IgG沉積的認(rèn)識(shí),延緩IgA腎病的進(jìn)展。
[Abstract]:Objective to investigate the relationship between IgG deposition in Mesangial region and IgA deposition in patients with IgA nephropathy.Methods from November 2009 to February 2016, 122 patients with IgA nephropathy were diagnosed by renal biopsy in the third affiliated Hospital of Southern Medical University.All renal biopsy samples were examined by light microscopy, immunofluorescence and electron microscopy.According to the results of immunofluorescence, the patients with IgA nephropathy were divided into IgA deposition group (n = 63) and IgA-IgG deposition group (n = 59).All patients were graded with Lee and Oxford.The clinical and pathological differences were compared between the two groups.Results the levels of 24 hour urinary protein, serum uric acid and triglyceride in IgA nephropathy with IgG deposition group were significantly higher than those in IgA deposition group (P 0. 05%, P 0. 001), and there were more patients in Lee grade IV-V grade in pathology.The ratio of tubular atrophy or / and interstitial fibrosis score and MEST score 鈮，

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