本文選題：熒光原位雜交　切入點(diǎn)：膀胱腫瘤　出處：《中華醫(yī)院感染學(xué)雜志》2009年14期

【摘要】：目的應(yīng)用染色體特異性探針對(duì)尿脫落細(xì)胞進(jìn)行FISH分析膀胱移行細(xì)胞癌的染色體畸變。方法選用3、7、9、17號(hào)染色體特異性探針對(duì)50例膀胱移行細(xì)胞癌患者尿液的脫落細(xì)胞進(jìn)行熒光原位雜交研究,并同時(shí)做細(xì)胞學(xué)檢查。結(jié)果膀胱癌患者尿液脫落細(xì)胞中3、7、9、17號(hào)染色體數(shù)目畸變陽性率分別為28%、32%、56%和38%,其中9號(hào)染色體畸變率較高,但與膀胱癌的分級(jí)無明顯相關(guān)關(guān)系;3、7和17號(hào)染色體數(shù)目畸變與膀胱癌的分期密切相關(guān)。結(jié)論膀胱癌的發(fā)生發(fā)展與染色體的畸變有關(guān),應(yīng)用FISH檢測膀胱癌患者尿液細(xì)胞染色體數(shù)目畸變,可以作為膀胱癌診斷、預(yù)后判斷的一項(xiàng)輔助方法,該方法具有快速、準(zhǔn)確、靈敏度高的優(yōu)點(diǎn)。
[Abstract]:Objective to analyze chromosomal aberration of bladder transitional cell carcinoma (TCC) by FISH with chromosome specific probe.Methods the exfoliated cells from 50 patients with transitional cell carcinoma of bladder were studied by fluorescence in situ hybridization with specific probes of chromosome 3 and chromosome 17, and cytological examination was also performed at the same time.Results in urine exfoliated cells of bladder cancer patients, the positive rates of chromosome 3, 7 and 17 were 2832, 56% and 38, respectively, and the rate of chromosome 9 was higher.However, there was no significant correlation between the number aberration of chromosome 37 and chromosome 17 and the stage of bladder cancer.Conclusion the occurrence and development of bladder cancer is related to chromosome aberration. The detection of chromosome aberration in urine by FISH can be used as an auxiliary method for the diagnosis and prognosis of bladder cancer. This method is rapid and accurate.The advantage of high sensitivity.
【作者單位】： 第三軍醫(yī)大學(xué)西南醫(yī)院檢驗(yàn)科;第三軍醫(yī)大學(xué)西南醫(yī)院泌尿外科;
【基金】：衛(wèi)生部科研基金項(xiàng)目(WKJ2007-3-001)
【分類號(hào)】：R737.14

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