發(fā)布時(shí)間：2018-03-16 16:26

  本文選題：前列腺癌　切入點(diǎn)：癌癥相關(guān)性乏力　出處：《腫瘤防治研究》2016年06期 　論文類型：期刊論文

【摘要】：目的評價(jià)調(diào)強(qiáng)放療聯(lián)合內(nèi)分泌治療對局部晚期前列腺癌乏力癥狀的影響。方法對符合納入標(biāo)準(zhǔn)的局部晚期前列腺癌患者采用同期三維適形調(diào)強(qiáng)放療聯(lián)合內(nèi)分泌治療。采用FSI(Fatigue Symptom Inventory)量表進(jìn)行長期問卷隨訪,調(diào)查時(shí)間分別為治療前(A)、治療結(jié)束后(B)、治療結(jié)束3月(C)、12月(D)、24月(E)、36月(F)、48月(G)。隨訪內(nèi)容包括疲勞程度、對生活質(zhì)量影響程度及上周疲勞持續(xù)時(shí)間3個(gè)維度。Logistic多分類回歸模型評價(jià)危險(xiǎn)因素。結(jié)果共97例局部晚期前列腺癌患者納入研究。中位隨訪時(shí)間43.9月。乏力指數(shù)與PSA水平、Gleason評分、ECOG評分及文化程度相關(guān)(P0.05);年齡和臨床分期與乏力指數(shù)無關(guān)(P0.05);多分類回歸分析顯示P S A水平和E C O G評分是癌癥相關(guān)性乏力的獨(dú)立危險(xiǎn)因素。疲勞程度在各個(gè)隨訪時(shí)間點(diǎn)未體現(xiàn)出差異(P0.05),但最嚴(yán)重疲乏程度發(fā)生在時(shí)間點(diǎn)B和C;時(shí)間點(diǎn)C、D、E、F和G的疲乏對生活影響積分均高于基線評價(jià),且差異有統(tǒng)計(jì)學(xué)意義(P0.05),尤其是對日�；顒�(dòng)影響積分、注意力積分和情緒積分。疲乏持續(xù)時(shí)間呈現(xiàn)波動(dòng)狀態(tài),時(shí)間點(diǎn)D、E、F呈明顯上升,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論ECOG評分高、Gleason≥8分、PSA20ng/ml、且文化程度高的局部晚期前列腺癌患者,在接受同期放療聯(lián)合內(nèi)分泌治療后,要關(guān)注乏力對生活質(zhì)量產(chǎn)生的影響,特別是在對日�；顒�(dòng)、注意力和情緒方面。
[Abstract]:Objective to evaluate the effect of intensity modulated radiotherapy (IMRT) combined with endocrine therapy on the symptoms of locally advanced prostate cancer. Methods three dimensional conformal intensity modulated radiotherapy combined with endocrine therapy was used in patients with locally advanced prostate cancer. The long-term questionnaire was followed up with FSI(Fatigue Symptom inventory. The time of investigation was before treatment, after treatment, after treatment, after treatment, on March, on December, 24 months, 36 months, 36 months, and 48 months, respectively. The follow-up included the degree of fatigue. Logistic multiple regression model was used to evaluate the risk factors. Results 97 patients with locally advanced prostate cancer were included in the study. The median follow-up time was 43.9 months. There was no correlation between age and clinical stage and fatigue index (P 0.05). Multiple classification regression analysis showed that PSA level and ECOG score were independent risk factors of cancer related fatigue. There was no significant difference in fatigue at all follow-up time points (P 0.05), but the most severe fatigue occurred at time points B and C, and the scores of fatigue effects on life at time points C and G were higher than those at baseline. The difference was statistically significant (P 0.05), especially for the scores of daily activity, attention and emotion. Conclusion the patients with advanced prostate cancer with high ECOG score (Gleason 鈮，

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