本文關(guān)鍵詞： 睪丸活檢術(shù) 血清抑制素B 抗精子抗體 卵泡刺激素 睪酮　出處：《中華男科學(xué)雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的:研究不同睪丸活檢術(shù)對無精子癥患者血清抑制素B(INHB)、血清抗精子抗體(As Ab)、卵泡刺激素(FSH)、睪酮(T)的影響。方法:選取無精子癥患者210例,根據(jù)不同的睪丸活檢手術(shù)方式,分為睪丸切開活檢取精術(shù)(TESE)組50例、睪丸穿刺抽吸取精術(shù)(TESA)組56例、睪丸細(xì)針穿刺抽吸取精術(shù)(TEFNA)組64例、顯微睪丸切開取精術(shù)(micro-TESE)組40例,分別檢測睪丸活檢術(shù)前及術(shù)后1、3個(gè)月患者血清INHB、FSH、T水平和As Ab陽性率。結(jié)果:4組患者術(shù)后1、3個(gè)月FSH與術(shù)前比較均無顯著性差異[TESE:(8.76±3.07)IU/L、(7.24±3.32)IU/L vs(8.51±4.34)IU/L;TESA:(7.90±4.57)IU/L、(8.04±3.65)IU/L vs(7.70±2.72)IU/L;TEFNA:(6.08±2.70)IU/L、(6.10±3.32)IU/L vs(6.04±3.17)IU/L;micro-TESE:(6.89±1.78)IU/L、(6.75±2.57)IU/L vs(6.59±2.74)IU/L,P均0.05]。TESE組和micro-TESE組術(shù)后1個(gè)月As Ab Ig M陽性率(14.00%和15.00%)較術(shù)前(0.00和2.50%)明顯升高(P0.05)。TESE組和micro-TESE組患者術(shù)后1個(gè)月T水平[(9.25±5.76)nmol/L和(8.23±4.12)nmol/L]較術(shù)前[(16.52±6.25)nmol/L和(14.16±5.45)nmol/L]明顯下降(P均0.05)。TESE、TESA、TEFNA、micro-TESE4組患者術(shù)后1、3個(gè)月血清INHB較術(shù)前均明顯下降[TESE:(42.63±15.34)pg/ml、(44.05±18.47)pg/ml vs(70.56±23.17)pg/ml;TESA:(40.55±20.51)pg/ml、(42.11±19.34)pg/ml vs(68.71±14.74)pg/ml;TEFNA:(46.31±19.28)pg/ml、(48.32±20.54)pg/ml vs(76.81±27.04)pg/ml;micro-TESE:(45.27±18.83)pg/ml、(47.64±28.34)pg/ml vs(74.74±28.35)pg/ml,P均0.05],但不同方法組組間無統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:不同睪丸活檢術(shù)對無精子癥患者睪丸功能及As Ab有影響,且存在一定差異。
[Abstract]:Objective: to study the effects of different testicular biopsy on serum inhibin INHBN, serum anti-sperm antibody (as Aba), follicle stimulating hormone (FSH) and testosterone (T) in patients with azoospermia. Methods: 210 patients with azoospermia were selected according to different methods of testicular biopsy. The patients were divided into testicular biopsy group (50 cases), testicular aspiration group (56 cases), fine needle aspiration group (64 cases) and micro-testicular extraction group (40 cases). The serum INHBFSHT level and Asab positive rate were measured before testicular biopsy and 1 and 3 months after testicular biopsy respectively. Results there was no significant difference in serum INHBFSHT level and Asab positive rate between 1 and 3 months after operation in the four groups. Results there was no significant difference in FSH between the 4 groups after operation [TESE:(8.76 鹵3.07 vs(8.51 鹵4.34 IUL vs(8.51 鹵3.32 vs(8.51 鹵4.34 IUL vs(8.51 7.90 鹵4.57 vs(8.51 鹵8.04 鹵3.65 vs(7.70 鹵2.72IUL vs(7.70 鹵2.70 FSH 6.08 鹵2.70 TESE:(8.76 vs(6.04 6.10 鹵3.32? The positive rate of Asab IgM (14.00% and 15.00%) was significantly higher than that before operation (P < 0.05). Tese group and micro-TESE group were significantly higher than those before operation [9.25 鹵5.76nmol / L and 8.23 鹵4.12nmol / L] significantly lower than those before operation [16.52 鹵6.25nmol / L and 14.16 鹵5.45nmol / L] (P = 0.05N. TESATEFNAmicro-TESE4 group), and the serum INHB was decreased significantly at 3 months after operation (P = 0.05nmol / L, P = 0.05nmol / L, P = 0.05nmol / L, P = 0.05N / L, P < 0.05). The serum INHB level was significantly lower at 3 months after operation than that before operation [16.52 鹵6.25nmol / L and 14.16 鹵5.45nmol / L]. [TESE:(42.63 鹵15.34 vs(68.71 鹵14.74 PG / ml TEFNAV 44.05 鹵18.47 PG / ml vs(70.56 鹵23.17 p / g / ml TESAN 40.55 鹵20.51 PG / ml 42.11 鹵19.34 vs(68.71 鹵14.74 g / ml TEFNAG / ml TEFNAV 46.31 鹵19.28 PG / ml 48.32 鹵20.54pg / ml vs(76.81 鹵27.04pgmlmicro-TESAN 45.27 鹵18.83pgml / ml 47.64 鹵28.34pgml vs(74.74 鹵28.35pgmlml P 0.05 respectively] conclusion: testicular microtesticular microtest has an effect on testicular function in patients with azoospermia (45.27 鹵18.83pgml-1 + 47.64 鹵28.34pgml 鹵28.35pgmlml P 0.05). And there are some differences.
【作者單位】： 溫州醫(yī)科大學(xué)附屬第二醫(yī)院生殖醫(yī)學(xué)中心;
【分類號】：R698.2

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相關(guān)期刊論文 前3條

1 石亮;李衛(wèi)巍;周雪;徐志鵬;張春華;;血清抑制素B檢測在無精子癥患者經(jīng)睪丸抽吸術(shù)結(jié)局預(yù)評估中的應(yīng)用[J];中華男科學(xué)雜志;2016年12期

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本文編號：1538341