【摘要】：目的:探討可樂定透皮貼片治療抽動障礙的療效和安全,建立可樂定透皮貼劑治療對象的預(yù)測模型。方法:選擇41例符合納入標(biāo)準(zhǔn)的抽動障礙患兒,采用前瞻性、開放性、單組、自身前后對照方法,給予可樂定透皮貼片治療12周,分別在入組時、4周、8周、12周用耶魯抽動癥整體嚴(yán)重程度量表進行評估。結(jié)果:⑴可樂定透皮貼劑治療4周、8周、12周時,總有效率分別為29.27%、53.66%、63.41%,與入組時相比有顯著統(tǒng)計學(xué)差異。⑵治療4周和8周時,運動性抽動、發(fā)聲性抽動、總抽動癥狀和功能損害4項因子的減分率與25%水平相比,均無統(tǒng)計學(xué)差異。治療12周時,運動性抽動及總抽動癥狀減分率與25%水平相比,有統(tǒng)計學(xué)差異。⑶病程≤24個月,入組時運動性抽動評分16,有效率為100%;病程≤24個月,運動性抽動評分≥16,有效率為57.1%;病程24個月,臨床分型為慢性抽動障礙,有效率為62.5%;病程24個月,臨床分型為抽動穢語綜合征,無效率為90%。⑷不良反應(yīng)主要為貼片處皮疹、輕微頭暈頭痛。結(jié)論:⑴多巴胺D2受體阻滯劑治療效果不佳的抽動障礙患兒,換用可樂定治療依然可能有效而安全。⑵可樂定透皮貼片可作為輕中型、以運動性抽動為主要表現(xiàn)的患兒的首選藥。
[Abstract]:Objective: to investigate the efficacy and safety of clonidine transdermal patch in the treatment of tic disorder and to establish a predictive model of clonidine transdermal patch. Methods: 41 children with tic disorders who met the inclusion criteria were treated with clonidine transdermal patch for 12 weeks. The patients were evaluated with Yale holistic severity scale at 4 weeks, 8 weeks and 12 weeks after admission. Results the total effective rates were 29.27% 53.66 and 63.41 respectively at 4 weeks and 8 weeks and 12 weeks after treatment with 1: 1 clonidine patch. There was significant difference between the two groups at 4 weeks and 8 weeks after treatment, the total effective rates were motor twitch and vocal twitch, and the total effective rates were 29. 27%, 53. 66% and 63. 41% at 4 and 8 weeks after treatment respectively, and there was significant difference between the two groups at 4 and 8 weeks. There was no statistical difference between the four factors of total tic symptoms and functional impairment compared with the 25% level. After 12 weeks of treatment, the reduction rate of motor tic and total tic symptoms was significantly lower than that of 25%, the course of disease was less than 24 months, the effective rate was 100, the course of disease was 鈮，

本文編號：2256128