本文關(guān)鍵詞：下呼吸道感染細菌菌譜及耐藥性5年動態(tài)變化分析，由筆耕文化傳播整理發(fā)布。

下呼吸道感染細菌菌譜及耐藥性5年動態(tài)變化分析

Dynamic analysis on bacterium spectrum and drug resistance of lower respiratory tract infections for consecutive 5 years

[1] [2] [3] [4] [5]

LIU Dan-dan, SHEN Ji-lu, DAI Meng-yuan , XU Yuan-hong , FEI Guang-he（ 1. Department of Respirato- ry Medicine, the First Affiliated Hospital of Anhui Medical University, Hefe

[1]安徽醫(yī)科大學第一附屬醫(yī)院呼吸內(nèi)科,安徽合肥230022; [2]安徽省第二人民醫(yī)院呼吸內(nèi)科,安徽合肥230041; [3]安徽醫(yī)科大學第一附屬醫(yī)院檢驗科,安徽合肥230022

文章摘要：目的對安徽醫(yī)科大學第一附屬醫(yī)院近5年住院患者下呼吸道感染細菌菌譜及耐藥性進行調(diào)查，指導臨床合理使用抗菌藥物。方法對安徽醫(yī)科大學第一附屬醫(yī)院2009年1月-2013年12月住院患者痰液細菌培養(yǎng)標本進行回顧性分析，本次研究，數(shù)據(jù)錄入采用WHONET5．6軟件，數(shù)據(jù)分析采用SPSS17．0軟件。結(jié)果共收集下呼吸道痰液標本37410例，細菌培養(yǎng)陽性結(jié)果6564例，其中革蘭氏陽性菌和革蘭氏陰性菌分別是617株（9．4％）和5947株（90．6％）。鮑曼不動桿菌和銅綠假單胞菌分別位于細菌檢出率的前兩位，呈逐年增長趨勢，其次是肺炎克雷伯菌，年檢出率呈遞減趨勢。耐藥性分析結(jié)果顯示，，銅綠假單胞菌對阿米卡星和四代頭孢菌素的耐藥率低，多在20．0％以下。鮑曼不動桿菌對頭孢哌酮／舒巴坦和米諾環(huán)素的耐藥率較其他藥物低。金黃色葡萄球菌耐藥率高，未發(fā)現(xiàn)耐萬古霉素、替考拉寧菌株。結(jié)論通過下呼吸道感染耐藥菌的監(jiān)測，有助于了解耐藥菌的分布及對抗生素的耐藥情況，指導臨床醫(yī)生合理使用抗生素，提高臨床治療效果。

Abstr：Objective To investigate the bacterial spectrum of lower respiratory tract and the drug resistance change in the first affiliated hospital of Anhui Medical University in recent five years, and to provide basis for the reasona- ble use of antibiotics in clinic. Methods A retrospective survey of the hospitalized patients with bacterial culture of spu- tum specimens from January 2009 to December 2013 was conducted. All the data were input WHONET 5.6 and statistically analyzed by SPSS 17.0. Results 6 564 bacteria strains were isolated with bacteria from 37 410 sputum spectimens of low- er respiratory tract, including gram-positive bacteria 617 （9. 4% ） and gram-negative bacteria 5 947 （90. 6% ）. The bacteri- a detection rate of acinetobacter baumannii and pseudomonas aeruginosa ranked in the top two, showed increasing trend, followed by klebsiella pneumoniae, whose detection rate presented decreasing trend. The resistance results showed that the resistance rate of pseudomonas aeruginosa against amikaein and the fourth generation cepbalosporins was about 20. 0% or lower. Staphylococcus ureus was resistant to many kinds of anti-biotics, however, no vancomycin and teicoplanin resistant strains were ＂found yet. Conclusions Through the surveillance of drug-resistant bacteria of lower respiratory tract infec- tions, help to understand the distribution of drug-resistant bacteria and bacterial resistance of antibiotics and guide the ra- tional use of antibiotics in clinic, and to improve the efficacy of treatment.

文章關(guān)鍵詞：

Keyword：:Respiratory tract infections Bacterial Epidemiologic methods

課題項目：國家衛(wèi)計委行業(yè)重大專項（201302003）

  本文關(guān)鍵詞：下呼吸道感染細菌菌譜及耐藥性5年動態(tài)變化分析，由筆耕文化傳播整理發(fā)布。