Objectives:Ovarian cancer with high mortality is one common subset of gynecological cancers. Further, G protein-coupled estrogen receptor （GPER/GPR30） is a novel estrogen receptor that mediates signaling pathway of estrogen. Current studies suggest that GPER/GPR30expression predicts poor outcome in breast cancer. Nevertheless, the impact of GPER/GPR30expression in ovarian cancer is unclear. The purpose of this study was to demonstrate the correlation of GPER/GPR30expression （protein/mRNA） and cl... 

【文章來源】：華中科技大學(xué)湖北省 211工程院校 985工程院校 教育部直屬院校

【文章頁數(shù)】：139 頁

【學(xué)位級別】：博士

【文章目錄】：
Abbreviation table
Abstract
Introduction
    1.1. Ovarian cancer
    1.2. G Protein-Coupled Estrogen Receptor-1
Material
    1.3. Material
    1.4. Cell and Tissue
    1.5. Source of tissue
Method
    Section 1 GPER/GPR30 expression of ovarian cancer in histology
    Section 2 GPER/GPR30 expression of ovarian cancer in cytology
    Section 3 GPER/GPR30 expression of ovarian cancer in gene level
    Section 4 Distribution of GPER/GPR30 in ovarian cancer cell
    Section 5 Statistical analysis
Results
    1. GPER/GPR30 expression of ovarian cancer in histological level
    2. GPER/GPR30 expression of ovarian cancer in cytological level
    3. GPER/GPR30 expression in ovarian cancer in gene level
    4. Distribution variant of GPER/GPR30 in ovarian cancer
    5. Correlations between GPER/GPR30 expression at protein level and the cinicopathological features of ovarian cancer
    6. Prognostic impact of GPER/GPR30 protein expression in ovarian cancer
Discussion
Conclusion
Reference
Review
    Reference
Publication
Acknowledgments



本文編號：3497362