【摘要】：目的檢測子宮內(nèi)膜異位性疾病患者子宮內(nèi)膜組織中表皮生長因子受體(EGFR)和上皮間質(zhì)轉(zhuǎn)化相關(guān)蛋白鈣黏附蛋白E(E-cadherin)、波形蛋白(vimentin)及snail的表達,探討其意義。方法采用免疫組化SP法檢測23例子宮腺肌病患者的在位及異位內(nèi)膜組織(腺肌病在位組及異位組)、19例子宮內(nèi)膜異位癥患者的異位內(nèi)膜組織(異位癥組)、20例子宮肌瘤患者的正常內(nèi)膜組織(對照組)EGFR、snail、E-cadherin、vimentin表達,分析異位子宮內(nèi)膜組織(異位癥組及腺肌病異位組)E-cadherin和vimentin表達的相關(guān)性。結(jié)果異位癥組EGFR陽性表達率(10.52%)低于對照組(40.00%),腺肌病異位組(82.61%)、在位組(56.52%)及異位癥組(78.95%)內(nèi)膜組織snail陽性表達率均高于對照組(55.00%),異位癥組(15.79%)和腺肌病異位組(30.43%)內(nèi)膜組織E-cadherin陽性表達率低于對照組(60.00%),異位癥組(89.47%)及腺肌病異位組(86.96%)vimentin陽性表達率均高于對照組(65.00%);各組比較,P均0.05。異位子宮內(nèi)膜組織(異位癥組及腺肌病異位組)E-cadherin和vimentin表達呈負相關(guān)(r=-0.372,P0.05)。結(jié)論子宮內(nèi)膜異位性疾病患者子宮內(nèi)膜組織EGFR、E-cadherin表達下調(diào),snail、vimentin表達上調(diào),上述因子的表達變化可能參與子宮內(nèi)膜異位性疾病的發(fā)生。
[Abstract]:Objective to detect the expression of epidermal growth factor receptor (EGFR) and epithelial stroma transformation associated protein calcium adhesion protein E (E-cadherin), viritin (vimentin) and snail in patients with Endometriosis. Methods Immunohistochemical SP method was used to detect the expression of EGFR,snail,E-cadherin,vimentin in eutopic and ectopic intimal tissue of 23 patients with adenomyosis (adenomyosis group and ectopic group), ectopic intimal tissue of 19 patients with Endometriosis (ectopic group) and normal intimal tissue of 20 patients with uterine myoma (control group). To analyze the correlation between the expression of E-cadherin and vimentin in ectopic endometrium (ectopic group and adenomyosis group). Results the positive expression rate of EGFR in ectopic group (10.52%) was lower than that in control group (40.00%), adenomyosis ectopic group (82.61%), located group (56.52%) and ectopic group (78.95%). The positive expression rate of snail in intimal tissue of ectopic group was higher than that of control group (58.00%). The positive expression rate of E-cadherin in ectopic group (15.79%) and adenomyosis group (30.43%) was lower than that in control group (60.00%). The positive expression rate of vimentin in ectopic group (89.47%) and adenomyosis ectopic group (86.96%) was higher than that in control group (65.00%). P was 0.05 in all groups. The expression of E-cadherin and vimentin in ectopic endometrium (ectopic group and adenomyosis group) was negatively correlated (r 鈮，

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