【摘要】：目的探討Wnt信號通路成分Wnt-5a和β-連接蛋白(β-catenin)在卵巢癌發(fā)生、發(fā)展中的作用。方法應用免疫組織化學二步法檢測60份卵巢癌組織中Wnt-5a和β-catenin表達;分析其表達與卵巢癌臨床病理特征、預后的關系以及兩者表達的相關性。結果 Wnt-5a在卵巢癌組織中陽性表達率為61.7%(37/60),其陽性表達與卵巢癌患者年齡、腫瘤大小、組織學類型、病理分級無明顯相關性(P均0.05),與腫瘤轉(zhuǎn)移相關(P0.05)。β-catenin在卵巢癌組織中陽性表達率為71.7%(43/60),其陽性表達與腫瘤的分期和轉(zhuǎn)移相關(P均0.05)。Wnt-5a和β-catenin陽性表達患者生存時間明顯低于陰性表達患者(P0.05)。Spearman法分析顯示兩者表達呈正相關(r=0.344,P=0.011)。在發(fā)生轉(zhuǎn)移的患者中Wnt-5a與β-catenin共同陽性表達率高達70%(24/34)。結論 Wnt-5a和β-catenin通過非經(jīng)典和經(jīng)典Wnt通路在卵巢癌發(fā)展中發(fā)揮重要作用,兩者高表達可能協(xié)同促進腫瘤轉(zhuǎn)移,提示預后不良。
[Abstract]:Objective to investigate the role of Wnt signaling pathway components Wnt-5a and 尾-junction protein (尾-catenin) in the occurrence and development of ovarian cancer. Methods Immunohistochemical two-step method was used to detect the expression of Wnt-5a and 尾-catenin in 60 samples of ovarian cancer, and the relationship between the expression and clinicopathological features and prognosis of ovarian cancer and the correlation between them were analyzed. Results the positive expression rate of Wnt-5a in ovarian cancer tissues was 61.7% (37 鈮，

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