【摘要】：目的探討外陰濕疣和宮頸炎癥與宮頸人乳頭狀瘤病毒(HPV)亞臨床感染(SPI)之間的相關(guān)性,為預(yù)防HPV感染提供依據(jù)。方法選取2012年6月-2013年9月126例接受治療的患者作為研究對(duì)象,根據(jù)病因分為外陰濕疣組69例和宮頸炎癥組57例,選取同期正常女性50名作為對(duì)照組;采用陰道鏡檢查并鏡下取組織進(jìn)行病理診斷,以判斷是否有HPV亞臨床感染;同時(shí)對(duì)3組個(gè)體鏡下所取組織標(biāo)本進(jìn)行熒光定量PCR檢測(cè)、HC2-HPV-DNA檢測(cè),以判斷個(gè)體是否有高危型HPV感染,并對(duì)患者進(jìn)行密切隨訪。結(jié)果外陰濕疣組與宮頸炎癥組患者HPV亞臨床感染分別為36、13例,感染率52.17%、22.81%,兩者之間差異有統(tǒng)計(jì)學(xué)意義(P0.05),兩組感染率與對(duì)照組相比,差異有統(tǒng)計(jì)學(xué)意義(χ2=30.95、7.82,P0.01);通過(guò)雜交捕獲試驗(yàn),外陰濕疣組、宮頸炎癥組與對(duì)照組高危HPV感染分別為29、15、4例,高危HPV感染率分別為42.03%、26.32%與8.00%,外陰濕疣組與宮頸炎癥組患者之間差異無(wú)統(tǒng)計(jì)學(xué)意義,但與對(duì)照組相比,差異有統(tǒng)計(jì)學(xué)意義(χ2=16.75、6.12,P0.05)。結(jié)論外陰濕疣、宮頸炎癥患者宮頸HPV亞臨床感染率和高危HPV感染率高于正常人群,要高度關(guān)注外陰濕疣和宮頸炎癥患者,做好隨訪和宣傳工作,以預(yù)防由HPV感染引起的其他婦科疾病的發(fā)生。
[Abstract]:Objective to investigate the relationship between vulvar condyloma and cervical inflammation and cervical human papillomavirus (HPV) subclinical infection of (SPI), and to provide evidence for the prevention of HPV infection. Methods from June 2012 to September 2013, 126 patients were divided into vulvar condyloma verruca group (69 cases) and cervical inflammation group (57 cases), 50 normal women were selected as control group, colposcopy and endoscopic examination were used for pathological diagnosis to determine whether there was subclinical infection of HPV. At the same time, fluorescence quantitative PCR and HC2-HPV-DNA were performed to determine whether the individuals had high risk HPV infection, and the patients were followed up closely. Results the subclinical infection of HPV in vulvar condyloma verruca group and cervical inflammation group was 36, 13 cases, the infection rate was 52.17% and 22.81% respectively. There was significant difference between the two groups (P 0.05). The infection rate of the two groups was significantly different from that of the control group (蠂 2 鈮，

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