復發(fā)性流產(chǎn)患者蛻膜和絨毛組織中TNF-α、水通道蛋白1的表達變化及意義
發(fā)布時間:2019-07-08 11:37
【摘要】:目的觀察復發(fā)性流產(chǎn)(RSA)患者蛻膜和絨毛組織中TNF-α、水通道蛋白(AQP)1的表達變化,并探討其意義。方法采用免疫組化法對60例RSA患者(RSA組)和20例正常早孕人工流產(chǎn)者(對照組)蛻膜及絨毛組織中的TNF-α、AQP1進行檢測。結(jié)果 RSA組、對照組蛻膜組織TNF-α陽性表達率分別為80%(48/60)、60.0%(12/20),AQP1陽性表達率分別為42%(25/60)、55%(11/20),兩組兩指標相比,P均0.05。RSA組、對照組絨毛組織中TNF-α陽性表達率分別為75%(45/60)、15%(3/20),AQP1陽性表達率分別為20%(12/60)、25%(15/20),兩組兩指標相比,P均0.05。RSA組絨毛組織中TNF-α與AQP1的表達呈負相關(guān)(r=-0.385、P0.05)。結(jié)論 RSA患者絨毛組織中TNF-α表達增加、AQP1表達減少,而且兩者的表達水平呈負相關(guān)關(guān)系;TNF-α、AQP1可能共同參與了RSA的發(fā)病過程。
[Abstract]:Objective to observe the expression of TNF- 偽 and aquaporin (AQP) 1 in decidua and villi of patients with recurrent abortion (RSA) and to explore their significance. Methods Immunohistochemical method was used to detect TNF- 偽 and AQP1 in decidua and villi of 60 patients with RSA (RSA group) and 20 patients with normal early pregnancy induced abortion (control group). Results in RSA group, the positive expression rates of TNF- 偽 in decidua of control group were 80% (48 鈮,
本文編號:2511556
[Abstract]:Objective to observe the expression of TNF- 偽 and aquaporin (AQP) 1 in decidua and villi of patients with recurrent abortion (RSA) and to explore their significance. Methods Immunohistochemical method was used to detect TNF- 偽 and AQP1 in decidua and villi of 60 patients with RSA (RSA group) and 20 patients with normal early pregnancy induced abortion (control group). Results in RSA group, the positive expression rates of TNF- 偽 in decidua of control group were 80% (48 鈮,
本文編號:2511556
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