【摘要】：目的觀察復(fù)發(fā)性流產(chǎn)(RSA)患者蛻膜和絨毛組織中TNF-α、水通道蛋白(AQP)1的表達(dá)變化,并探討其意義。方法采用免疫組化法對(duì)60例RSA患者(RSA組)和20例正常早孕人工流產(chǎn)者(對(duì)照組)蛻膜及絨毛組織中的TNF-α、AQP1進(jìn)行檢測(cè)。結(jié)果 RSA組、對(duì)照組蛻膜組織TNF-α陽(yáng)性表達(dá)率分別為80%(48/60)、60.0%(12/20),AQP1陽(yáng)性表達(dá)率分別為42%(25/60)、55%(11/20),兩組兩指標(biāo)相比,P均0.05。RSA組、對(duì)照組絨毛組織中TNF-α陽(yáng)性表達(dá)率分別為75%(45/60)、15%(3/20),AQP1陽(yáng)性表達(dá)率分別為20%(12/60)、25%(15/20),兩組兩指標(biāo)相比,P均0.05。RSA組絨毛組織中TNF-α與AQP1的表達(dá)呈負(fù)相關(guān)(r=-0.385、P0.05)。結(jié)論 RSA患者絨毛組織中TNF-α表達(dá)增加、AQP1表達(dá)減少,而且兩者的表達(dá)水平呈負(fù)相關(guān)關(guān)系;TNF-α、AQP1可能共同參與了RSA的發(fā)病過程。
[Abstract]:Objective to observe the expression of TNF- 偽 and aquaporin (AQP) 1 in decidua and villi of patients with recurrent abortion (RSA) and to explore their significance. Methods Immunohistochemical method was used to detect TNF- 偽 and AQP1 in decidua and villi of 60 patients with RSA (RSA group) and 20 patients with normal early pregnancy induced abortion (control group). Results in RSA group, the positive expression rates of TNF- 偽 in decidua of control group were 80% (48 鈮，

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