【摘要】：目的探討原發(fā)性子宮頸小細(xì)胞癌(small cell carcinoma of the cervix,SCCC)的臨床病理學(xué)特征、免疫表型及預(yù)后。方法采用免疫組化SP法和原位雜交法對(duì)18例SCCC進(jìn)行臨床病理學(xué)觀察,并結(jié)合文獻(xiàn)復(fù)習(xí)。結(jié)果 18例SCCC患者年齡30~69歲,平均40歲。SCCC患者臨床表現(xiàn)均為陰道不規(guī)則出血。婦科檢查:子宮頸腫塊或子宮頸糜爛。組織學(xué)特征:SCCC腫瘤細(xì)胞小而一致,可呈圓形似淋巴細(xì)胞,但較淋巴細(xì)胞大,或呈雀麥形,或部分呈短梭形,細(xì)胞質(zhì)少,境界不清,核染色質(zhì)呈細(xì)顆粒狀,深染,核仁不明顯,核分裂象多見(jiàn)。免疫表型:腫瘤細(xì)胞通常表達(dá)CKpan,并不同程度地表達(dá)Syn、NSE、Cg A、CD56和p16。原位雜交:檢測(cè)4例腫瘤細(xì)胞HPV 16/18陽(yáng)性。超微結(jié)構(gòu):腫瘤細(xì)胞內(nèi)可見(jiàn)神經(jīng)內(nèi)分泌顆粒。隨訪10例SCCC,6例患者2年內(nèi)死亡。結(jié)論 SCCC屬神經(jīng)內(nèi)分泌癌,是子宮頸少見(jiàn)的高度惡性腫瘤,預(yù)后差,其發(fā)生可能與HPV 16/18感染有關(guān)。CKpan、Syn、Cg A、NSE和CD56是SCCC的免疫標(biāo)志物,有利于輔助診斷。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotypes and prognosis of primary cervical small cell carcinoma (small cell carcinoma of the cervix,SCCC). Methods Immunohistochemical SP method and in situ hybrid method were used to observe the clinicopathology of 18 cases of SCCC, and the literature was reviewed. Results 18 patients with SCCC were 30 years old and 69 years old, with an average of 40 years old. The clinical manifestations of 18 patients with SCCC were irregular vaginal bleeding. Gynecological examination: cervical mass or cervical erosion. Histologic characteristics: SCCC tumor cells are small and consistent, can be round like lymphocytes, but larger than lymphocytes, or in the shape of Bromus, or part of them are short fusiform, less cellular quality, unclear boundary, nuclear chromatin is fine grain, deep staining, nucleolus is not obvious, mitosis is more common. Immunophenotypic: tumor cells usually express CKpan, and Syn,NSE,Cg A, CD56 and p16. In situ hybridization: the positive rate of HPV 16 鈮，

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