【摘要】：目的通過(guò)檢測(cè)和統(tǒng)計(jì)東營(yíng)市HPV各亞型在健康人群和宮頸疾病患者中的流行情況,指導(dǎo)當(dāng)?shù)豀PV預(yù)防性疫苗的開(kāi)發(fā)和引進(jìn)。方法留取健康體檢婦女以及各級(jí)宮頸上皮不典型增生和宮頸癌患者的宮頸脫落細(xì)胞,采用基因?qū)Я麟s交技術(shù)檢測(cè)21種HPV亞型,統(tǒng)計(jì)HPV各亞型在健康人群和宮頸疾病患者中的流行情況,分析當(dāng)?shù)亻_(kāi)發(fā)和引進(jìn)預(yù)防性HPV疫苗時(shí)所應(yīng)重點(diǎn)選擇的亞型。結(jié)果在6 401例健康體檢人群中,HPV總感染率為15.11%(967/6 401),檢出HPV 1 145株,各HPV亞型感染所占比例排名靠前依次為16型(23.23%)、52型(16.68%)、58型(10.22%)、53型(9.34%)、33型(6.29%)、18型(5.94%);在166例HPV感染的CINⅠ~Ⅱ患者中檢出HPV亞型198株,各HPV亞型感染所占比例排名靠前依次為16型(18.37%)、58型(14.29%)、31型(14.29%)、52(10.20%)、18型(9.18%)、68型(8.16%);在31例HPV感染的≥CINⅢ患者中檢出HPV亞型38株,各HPV亞型感染所占比例排名靠前依次為16型(36.84%)、31型(18.42%)、58型(15.79%)、18型(10.52%)、68型(7.89%)、33型(5.26%)。結(jié)論因HPV亞型的流行存在地域性,且各亞型的致病能力不同,所以各地區(qū)應(yīng)綜合考慮以上兩方面因素,有針對(duì)性地開(kāi)發(fā)和引進(jìn)HPV疫苗。就東營(yíng)市而言,如果以全面降低人群HPV感染為主要目的,應(yīng)考慮開(kāi)發(fā)和引進(jìn)以16、52、58和53型為主的HPV四聯(lián)預(yù)防性疫苗,可降低59.47%的HPV人群感染;如果以降低宮頸癌變?yōu)橹饕康?應(yīng)考慮開(kāi)發(fā)和引進(jìn)以16、31、58和18型為主的HPV四聯(lián)預(yù)防性疫苗,可降低81.57%CINⅢ以上宮頸病變的發(fā)生。
[Abstract]:Objective to detect and count the prevalence of HPV subtypes in healthy people and patients with cervical diseases in Dongying City, and to guide the development and introduction of local HPV prophylactic vaccine. Methods the cervical exfoliated cells of healthy women and patients with cervical epithelial atypical hyperplasia and cervical cancer were collected and 21 HPV subtypes were detected by gene diversion hybridom. the prevalence of HPV subtypes in healthy people and patients with cervical diseases was counted, and the subtypes that should be selected in the local development and introduction of prophylactic HPV vaccine were analyzed. Results among 6401 healthy people, the total infection rate of HPV was 15.11% (967 鈮，

本文編號(hào)：2509101