【摘要】：目的探討外周血Th17細(xì)胞數(shù)量與宮頸癌發(fā)生、發(fā)展的關(guān)系。方法選取宮頸癌初治患者50例(宮頸癌組),宮頸上皮內(nèi)瘤變(CIN)患者25例(CIN組),成年體檢健康女性25例(對(duì)照組)。采用流式細(xì)胞術(shù)檢測(cè)各組外周血Th17細(xì)胞占CD4+T細(xì)胞的比例;分析Th17細(xì)胞比例與宮頸癌患者臨床病理參數(shù)的關(guān)系。結(jié)果宮頸癌組、CIN組和對(duì)照組外周血Th17細(xì)胞比例分別為(2.02±0.46)%、(1.36±0.31)%、(0.58±0.19)%,組間兩兩比較P均0.01;外周血Th17細(xì)胞比例與宮頸癌患者國(guó)際婦產(chǎn)聯(lián)盟(FIGO)分期、淋巴結(jié)轉(zhuǎn)移、脈管浸潤(rùn)均呈正相關(guān)(r分別為0.74、0.43、0.54,P均0.05),與組織分化程度無(wú)關(guān)(P0.05)。結(jié)論宮頸癌患者外周血Th17細(xì)胞數(shù)量增多;Th17細(xì)胞增多可促進(jìn)宮頸癌的發(fā)生、發(fā)展。
[Abstract]:Objective to investigate the relationship between the number of Th17 cells in peripheral blood and the occurrence and development of cervical cancer. Methods 50 patients with cervical cancer (cervical cancer group), 25 patients with cervical intraepithelial neoplastic (CIN) (CIN group) and 25 healthy adult women (control group) were selected. The proportion of Th17 cells to CD4 T cells in peripheral blood of each group was detected by flow cytometry, and the relationship between the proportion of Th17 cells and clinicopathological parameters of cervical cancer patients was analyzed. Results the proportion of Th17 cells in peripheral blood of cervical cancer group, CIN group and control group was (2.02 鹵0.46)%, (1.36 鹵0.31)% and (0.58 鹵0.19)%, respectively. The proportion of Th17 cells in peripheral blood was positively correlated with (FIGO) stage, lymph node metastasis and vessel invasion of cervical cancer patients (r = 0.74, 0.43, 0.54, P < 0.05), but not with the degree of tissue differentiation (P 0.05). Conclusion the number of Th17 cells in peripheral blood of patients with cervical cancer is increased, and the increase of Th17 cells can promote the occurrence and development of cervical cancer.
【作者單位】： 新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院;新疆博州人民醫(yī)院;
【基金】：新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院科研啟動(dòng)基金項(xiàng)目(腫2014-04)
【分類(lèi)號(hào)】：R737.33

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