【摘要】：目的比較4種基于灰度的配準方法(剛性、仿射、B樣條彈性、關(guān)注感興趣區(qū)的彈性配準)對宮頸癌靶區(qū)器官在不同分次間的形變精度。方法選取30例宮頸癌患者,均分為3組,第1組的每個病例有2套不同分次外照射的CT圖像,第2組有2套不同分次后裝照射的CT圖像,第3組有單次外照射和單次后裝照射的CT圖像。首先,由同一個醫(yī)生勾畫所有CT圖像的GTV、直腸和膀胱,然后每一組分別使用上述4種方法進行配準,接著,在形變圖像上勾畫GTV、直腸和膀胱,與參考圖像上的GTV、直腸和膀胱進行比較,以它們的形變指數(shù)(由區(qū)域重疊度和輪廓適形指數(shù)組成)衡量4種配準方法的配準精度。結(jié)果在30例患者中,關(guān)注感興趣區(qū)的配準方法(簡稱ROI方法)的精度高于其他方法,在第1組中占優(yōu)的數(shù)量為直腸9例、膀胱10例、GTV 10例,第2組為直腸8例、膀胱9例、GTV 10例,第3組為直腸9例、膀胱10例、GTV 10例。與剛性配準方法的精度相比,第1組的ROI方法、B樣條彈性配準、仿射配準與它的差值分別為11%~64%、-18%~39%、-12%~11%,第2組為4%~56%、-17%~58%、-7%~68%,第3組為10%~76%、-17%~41%、-6%~20%。結(jié)論在不同分次放療宮頸癌的CT圖像進行配準時,ROI方法能提高腫瘤靶區(qū)、直腸和膀胱的配準精度,有利于準確地獲取它們在即往放療方案的總劑量。
[Abstract]:Objective to compare the deformation accuracy of four registration methods based on gray scale (rigid, affine, B-spline elasticity, elastic registration of region of interest) for cervical cancer target organs in different grades. Methods 30 patients with cervical cancer were divided into three groups. Each case in group 1 had two sets of CT images with different external irradiation, the second group had two sets of CT images with different stages of external irradiation, and the third group had CT images of single external irradiation and single afterirradiation. First, the GTV, rectum and bladder of all CT images were sketched by the same doctor, and then each group was registered with the above four methods respectively. then, the GTV, rectum and bladder were sketched on the deformation image and compared with the GTV, rectum and bladder on the reference image, and the registration accuracy of the four registration methods was measured by their deformation index (composed of regional overlap and conformal index). Results in 30 patients, the accuracy of the registration method of region of interest (ROI) was higher than that of other methods. In group 1, there were 9 cases of rectum, 10 cases of bladder, 10 cases of GTV, 8 cases of rectum, 9 cases of bladder, 10 cases of GTV, 9 cases of rectum, 10 cases of bladder and 10 cases of GTV in group 3. Compared with the accuracy of rigid registration method, the difference between group 1 ROI method, B-spline elastic registration, affine registration and rigid registration is 11% 64%, 18% 39%, 12% 11%, 4% 56%, 17% 58%, 7% 68%, 10% 76%, 17% 41%, 6% 20%, respectively. the difference between affine registration and rigid registration is 11% 64%, 18% 39%, 12% 11%, 4% 56%, 17% 58%, 7% 68%, 10% 76%, 17% 41%, 6% 20%, respectively. Conclusion ROI can improve the registration accuracy of tumor target, rectum and bladder, and is helpful to obtain the total dose of radiotherapy regimen in different stages of radiotherapy for cervical cancer.
【作者單位】： 廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院放療中心;廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院放射科;
【基金】：廣東省教育廳特色創(chuàng)新項目(自然科學(xué)類)(編號:2014KTSCX104) 廣州市醫(yī)藥衛(wèi)生科技一般引導(dǎo)項目(編號:20151A011085)
【分類號】：R737.33;TP391.41
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本文編號：2503689