【摘要】：目的：檢測PCOS患者血清GnSAF水平及與PCOS各項指標間的關系，探討其在PCOS發(fā)病的意義及其在臨床上的應用。 方法：選取76名PCOS患者、67名對照者和7名卵巢功能衰退者，計算PCOS組和對照組體重指數（BMI）及腰臀比（WHR），測定各研究對象血清性激素水平（卵泡刺激素(FSH)、黃體生成素(LH)、雌二醇(E2)、睪酮(T)）和GnSAF水平，行陰道超聲下卵泡監(jiān)測記錄卵泡大小及數目，并對PCOS組患者行OGTT和Ins釋放試驗。應用SPSS21.0軟件分析實驗組和對照組血清GnSAF水平有無差異，使用Pearson相關系數分析GnSAF與其他指標間的相關性。 結果: （1）研究對象共150例，其中PCOS組76例，，對照組67例，卵巢功能衰退者7例。PCOS與對照組年齡、WHR比較，差異無統(tǒng)計學意義，具有可比性；兩組BMI比較，差異有統(tǒng)計學意義。 （2）除FSH和E2外，PCOS組和對照組LH、T水平以及LH/FSH比值顯著大于對照組（P0.01，P0.01，P0.01），兩組間比較差異有統(tǒng)計學意義。 （3） PCOS組與對照組GnSAF水平分別為22.11±6.71pg/ml及20.11±5.92pg/ml，PCOS組高于對照組，但差異無統(tǒng)計學意義（P=0.062） （4） PCOS組GnSAF與FSH、E2呈負相關趨勢，與LH、T呈正相關趨勢，正常組GnSAF與各激素間呈負相關趨勢，但無統(tǒng)計學意義。 （5） GnSAF濃度與卵泡數呈正相關趨勢，與FSH呈負相關趨勢，差異有統(tǒng)計學意義。 結論： （1）血清GnSAF水平與PCOS發(fā)病、卵泡發(fā)育障礙無相關性，需大樣本進行進一步研究； （2）對預測卵巢儲備功能有意義。
[Abstract]:Objective: to detect the level of serum GnSAF and its relationship with PCOS in patients with PCOS, and to explore its significance in the pathogenesis of PCOS and its clinical application. Methods: 76 patients with PCOS, 67 controls and 7 patients with ovarian dysfunction were selected to calculate the body mass index (BMI) and waist hip ratio (WHR),) of body mass index (BMI) and waist hip ratio (WHR),) in PCOS group and control group. The levels of serum sex hormone (E 2), testosterone (T) and GnSAF (E 2), testosterone (T) and GnSAF were measured by vaginal ultrasound. OGTT and Ins release tests were performed in PCOS group. The difference of serum GnSAF level between experimental group and control group was analyzed by SPSS21.0 software, and the correlation between GnSAF and other indexes was analyzed by Pearson correlation coefficient. Results: (1) there were 76 cases in PCOS group, 67 cases in control group and 7 cases in ovarian dysfunction. There was no significant difference in age and WHR between PCOS and control group, and there was significant difference between BMI group and control group. (2) except FSH and E2, the level of LH,T and the ratio of LH/FSH in PCOS group and control group were significantly higher than those in control group (P0.01, P01), and there was significant difference between the two groups. (3) the levels of GnSAF in PCOS group and control group were 22.11 鹵6.71pg/ml and 20.11 鹵5.92pg 鈮

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