【摘要】：目的分析337例胎兒超聲軟指標(biāo)(USMs)陽性的染色體結(jié)果,并探討其與染色體異常的關(guān)系。方法對行產(chǎn)前診斷且USMs陽性的337例孕婦,統(tǒng)計染色體結(jié)果行回顧性分析,將研究對象分為單純USMs陽性組(A組,186例;1項USMs陽性為A1組,150例;2項及以上USMs陽性為A2組,36例),USMs陽性合并高齡或唐篩高風(fēng)險組(B組,82例),USMs陽性合并其他異常組(C組,69例),并分析其與染色體的聯(lián)系。結(jié)果 A1組、A2組染色體異常發(fā)生率比較,差異無統(tǒng)計學(xué)意義;A組與B組染色體異常率比較差異無統(tǒng)計學(xué)意義;A組與C組異常率比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論 USMs陽性可能增加染色體異常風(fēng)險,需正確評估其應(yīng)用價值以減少不必要的有創(chuàng)產(chǎn)前診斷,但是合并其他結(jié)構(gòu)異常,必須在染色體正常的前提下繼續(xù)妊娠。
[Abstract]:Objective to analyze the chromosome results of ultrasound soft index (USMs) positive in 337 fetuses and to explore the relationship between them and chromosome abnormalities. Methods the chromosome results of 337 pregnant women diagnosed before delivery and USMs positive were analyzed retrospectively. the subjects were divided into simple USMs positive group (group A, n = 186), 1 USMs positive group (n = 150), and 1 USMs positive group (n = 150). Two or more USMs positive groups were A2, 36), USMs positive patients with advanced age or high risk group (group B, 82), USMs positive patients with other abnormalities (group C, 69 patients), and the relationship with chromosomes was analyzed. Results there was no significant difference in the incidence of chromosome abnormalities between group A1 and group A2, there was no significant difference in the abnormal rate between group A and group B, and there was significant difference between group A and group C (P 0.05). Conclusion USMs positive may increase the risk of chromosome abnormalities. It is necessary to correctly evaluate its application value in order to reduce unnecessary invasive predelivery diagnosis, but with other structural abnormalities, it is necessary to continue pregnancy under the premise of normal chromosomes.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院婦產(chǎn)科產(chǎn)前診斷中心;
【基金】：安徽省自然科學(xué)基金(編號:1208085MH172) 安徽高校省級自然科學(xué)研究項目(編號:KJ2011Z215)
【分類號】：R714.5

【參考文獻(xiàn)】

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