【摘要】：目的:分析影響供精人工授精(AID)妊娠結(jié)局的相關(guān)因素,以提高妊娠率,并評(píng)價(jià)其子代安全性。方法:回顧性分析沈陽(yáng)二0四醫(yī)院生殖醫(yī)學(xué)研中心2005年7月1日至2013年6月30日行AID助孕的5 109例患者,共計(jì)7 761周期的妊娠結(jié)局及子代出生缺陷發(fā)生率情況。結(jié)果:AID臨床妊娠2 252例,周期妊娠率29.02%,累積妊娠率44.08%。女方年齡≤35歲組臨床妊娠率明顯高于35歲以上組(30.31%vs 20.18%,P0.01),不孕年限5年以下組高于5年以上組(30.83%vs 28.16%,P0.01),使用促排卵組臨床妊娠率明顯高于自然周期組(33.22%vs 28.68%,P0.01);治療第1周期組的臨床妊娠率最高(29.87%),與治療第4周期組妊娠率(23.61%)差異有統(tǒng)計(jì)學(xué)意義(P0.05),其余各治療周期組間的臨床妊娠率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。AID發(fā)生子代出生缺陷28例(1.40%),以心血管畸形發(fā)生率最高(6例,21.43%),其次是骨骼肌肉系統(tǒng)畸形4例(14.29%),泌尿系統(tǒng)和神經(jīng)系統(tǒng)畸形各3例(10.71%),還包括唇腭裂、呼吸系統(tǒng)、消化系統(tǒng)畸形各2例(7.14%)及其它系統(tǒng)畸形。結(jié)論:女方年齡、不孕年限及促排卵治療是影響AID臨床妊娠率的重要因素;冷凍精液行AID并未增加子代出生缺陷發(fā)生率,是一項(xiàng)相對(duì)安全的輔助生殖技術(shù)。
[Abstract]:Objective: to analyze the related factors affecting the pregnancy outcome of artificial indoctrination (AID) in order to improve the pregnancy rate and evaluate the safety of its offspring. Methods: from July 1, 2005 to June 30, 2013, 5109 patients with AID assisted pregnancy were analyzed retrospectively. the pregnancy outcome of 7 761 cycles and the incidence of birth defects in offspring were analyzed retrospectively. the pregnancy outcome of 7 761 cycles and the incidence of birth defects in offspring were analyzed retrospectively. the pregnancy outcome and the incidence of birth defects in offspring were analyzed. Results: there were 2252 clinical pregnancies in AID. The pregnancy rate was 29.02% and the cumulative pregnancy rate was 44.08%. The clinical pregnancy rate of the female group aged 鈮，

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