發(fā)布時(shí)間：2019-05-23 00:56

【摘要】：目的觀察宮頸上皮內(nèi)瘤變(CIN)及宮頸鱗癌組織中p16、Cullin4B(CUL4B)的表達(dá)變化。方法選取正常宮頸組織、CIN1、CIN2、CIN3、宮頸鱗癌組織標(biāo)本共計(jì)173例份,分為正常宮頸組30例、CIN1組33例、CIN2組38例、CIN3組40例、宮頸鱗癌組32例。采用免疫組化法檢測(cè)各組中的p16、CUL4B。結(jié)果正常宮頸組、CIN1組、CIN2組、CIN3組、宮頸鱗癌組p16蛋白表達(dá)陽性分別為1(3.33%)、13(39.39%)、30(78.95%)、40(100%)、32(100%)例;CUL4B表達(dá)陽性分別為0、11(33.33%)、29(76.32%)、40(100%)、32(100%)例。CIN各組和宮頸鱗癌組p16、CUL4B蛋白陽性表達(dá)率高于正常宮頸組,其中p16、CUL4B在CIN1、2、3組中的陽性表達(dá)率依次增高,在宮頸鱗癌組中的陽性表達(dá)率高于CIN1組和CIN2組(P均0.05)。p16、CUL4B在宮頸病變組織中的表達(dá)呈正相關(guān)(r=0.969,P0.01)。結(jié)論 CIN及宮頸鱗癌組織中p16、CUL4B表達(dá)高于正常宮頸組織,且隨著宮頸病變程度加重而增高。p16、CUL4B表達(dá)可能與宮頸病變的發(fā)生和進(jìn)展有關(guān),二者之間可能存在相互作用。
[Abstract]:Objective to observe the expression of p16, cullin 4 B (CUL4B) in cervical intraepithelial neoplastic (CIN) and cervical squamous cell carcinoma. Methods A total of 173 specimens of normal cervical tissue and CIN1,CIN2,CIN3, cervical squamous cell carcinoma were divided into normal cervical group (n = 30), CIN1 group (n = 33), CIN2 group (n = 38), CIN3 group (n = 40) and cervical squamous cell carcinoma group (n = 32). P16 and CUL4B in each group were detected by Immunohistochemical method. Results the positive rates of p16 protein expression in normal cervix group, CIN1 group, CIN2 group, CIN3 group and cervical carcinoma group were 1 (3.33%), 13 (39.39%), 30 (78.95%), 40 (100%) and 32 (100%), respectively. The positive expression of CUL4B was 0, 11 (33.33%), 29 (76.32%), 40 (100%) and 32 (100%), respectively. The positive expression rate of CUL4b protein in cin group and cervical carcinoma group was higher than that in normal cervix group, among which p16, CUL4b protein expression rate in CIN1,2, was higher than that in normal cervix group (33.33%), 29 (76.32%), 40 (100%) and 32 (100%) cases, respectively. The positive expression rate of p16 and CUL4B in cervical carcinoma group was higher than that in CIN1 group and CIN2 group (P < 0.05). There was a positive correlation between the expression of p16 and CUL4B in cervical lesions (r 鈮，

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