發(fā)布時(shí)間：2019-04-30 11:19

【摘要】：產(chǎn)前母體處于應(yīng)激狀態(tài)下,可以削弱子代的神經(jīng)系統(tǒng)對(duì)外界不良刺激影響的抵抗能力.但產(chǎn)前應(yīng)激狀態(tài)是否可以影響抗精神疾病藥物對(duì)動(dòng)物行為的增益作用,目前還沒有明確的結(jié)論.此外,在動(dòng)物實(shí)驗(yàn)中,動(dòng)物需要經(jīng)常接受注射操作,注射操作本身是否會(huì)影響動(dòng)物行為,尚未有相關(guān)研究.在本實(shí)驗(yàn)中,探索了產(chǎn)前輕微應(yīng)激狀態(tài)、圍產(chǎn)期注射操作和抗精神疾病藥物對(duì)動(dòng)物行為可能的交互影響.母鼠在經(jīng)歷產(chǎn)前輕微應(yīng)激狀態(tài)后生產(chǎn)子代,雄性仔鼠在圍產(chǎn)期(日齡第7,9,11天)不接受注射或接受鹽水或奧氮平注射(2 mg/kg,腹腔注射).在其亞成年期(日齡第35天)和成年期(日齡第60天),觀察其社交和嗅覺辨識(shí)行為,分析了總探索時(shí)間和對(duì)新舊刺激的偏好程度兩個(gè)參數(shù).我們發(fā)現(xiàn),圍產(chǎn)期重復(fù)注射操作可以改變產(chǎn)前應(yīng)激組大鼠在社交和嗅覺辨識(shí)實(shí)驗(yàn)中的偏好程度,對(duì)無應(yīng)激組大鼠沒有影響.奧氮平注射可以增長無應(yīng)激組大鼠在社交活動(dòng)中的總探索時(shí)間,對(duì)應(yīng)激組大鼠沒有影響.研究表明,產(chǎn)前輕微應(yīng)激狀態(tài)可以易化諸如圍產(chǎn)期注射操作等不良環(huán)境刺激導(dǎo)致的行為異常,并減弱抗精神疾病藥物的對(duì)神經(jīng)系統(tǒng)的影響.
[Abstract]:Prenatal stress can weaken the ability of the nervous system of the offspring to resist the adverse stimuli of the outside world. However, there is no clear conclusion as to whether prenatal stress can affect the effects of antipsychotic drugs on animal behavior. In addition, in animal experiments, animals need to be injected frequently, whether the injection itself affects animal behavior, there has been no relevant research. In this study, we explored the possible effects of prenatal mild stress, perinatal injection and antipsychotic drugs on animal behavior. During the perinatal period (7, 9, 11 days of age), the male offspring were not injected with saline or olanzapine (2 mg/kg, intraperitoneal injection) during the perinatal period (7, 9, 11 days of age). The social and olfactory identification behaviors were observed in their subadulthood (day 35) and adulthood (day 60). The total exploring time and the preference for new and old stimuli were analyzed. We found that repeated perinatal injection could change the preference of prenatal stress group rats in social and olfactory identification tests, but had no effect on non-stress group rats. Olanzapine injection could increase the total exploring time in social activities of non-stress group rats, but had no effect on stress group rats. Studies have shown that prenatal mild stress can facilitate behavioral abnormalities caused by adverse environmental stimuli such as perinatal injection and attenuate the effects of antipsychotic drugs on the nervous system.
【作者單位】： 腦與認(rèn)知國家重點(diǎn)實(shí)驗(yàn)室中國科學(xué)院生物物理研究所;中國科學(xué)院大學(xué);
【基金】：supported by grants from The State Major Research Project:What is a fundamental constituent of cognition(2012CB825500) the State Major Research Project:Brainnetome based on multimodal magnetic resonance imaging and its clinic application(2011CB707800) The National Natural Science Foundation of China(91132302) The Major Research Project of The National Natural Science Foundation of China:New methods and technologies for labeling the memory-related neural circuits(91132307)~~
【分類號(hào)】：R714.7

【共引文獻(xiàn)】

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2 胡華;王立偉;;喹硫平治療心境障礙的作用機(jī)制[J];上海精神醫(yī)學(xué);2008年01期

3 龔源;榮征星;王昊;祁紅;;內(nèi)源性大麻素系統(tǒng)對(duì)中樞神經(jīng)的調(diào)控及臨床應(yīng)用[J];中國臨床藥學(xué)雜志;2013年06期

4 柳昀哲;張丹丹;羅躍嘉;;社會(huì)神經(jīng)科學(xué)研究進(jìn)展[J];中國科學(xué):生命科學(xué);2014年06期

5 關(guān)素珍;夏迪亞·夏爾甫丁;徐仙;劉繼文;;孕前慢性應(yīng)激后仔鼠學(xué)習(xí)記憶與胰島素樣生長因子Ⅱ表達(dá)相關(guān)性研究[J];環(huán)境與職業(yè)醫(yī)學(xué);2014年06期

6 朱虹;賈z嚴(yán)，

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