【摘要】：目的比較核仁素在宮頸鱗癌、宮頸上皮內(nèi)瘤變和正常宮頸組織表達的差異,探討核仁素表達增高在宮頸鱗癌發(fā)生發(fā)展中的作用。方法用免疫組化檢測50例宮頸鱗癌、65例宮頸上皮內(nèi)瘤變和正常宮頸組織中核仁素的表達,比較核仁素在3種組織中表達的差異,并分析核仁素表達水平與宮頸鱗癌和宮頸上皮內(nèi)瘤變病理分級的關(guān)系。結(jié)果宮頸鱗癌核仁素陽性表達率顯著高于宮頸上皮內(nèi)瘤變和正常宮頸組織,宮頸上皮內(nèi)瘤變核仁素陽性表達率顯著高于正常宮頸組織,P0.01。Allred免疫組化半定量評分顯示,核仁素表達量在宮頸鱗癌組織(7.6±0.3)顯著高于宮頸上皮內(nèi)瘤變(6.1±0.2)和正常宮頸組織(3.0±0.2),P0.01。在宮頸上皮內(nèi)瘤變顯著高于正常宮頸組織,P0.01。核仁素表達量在中-低分化宮頸鱗癌(7.9±0.1)顯著高于高分化鱗癌(7.0±0.2),在高級別上皮內(nèi)瘤變(6.0±0.1)顯著高于低級別上皮內(nèi)瘤變組織(4.0±0.2),P0.01。結(jié)論宮頸鱗狀上皮在癌變過程中核仁素表達量增高,核仁素表達量增高與宮頸鱗癌和宮頸上皮內(nèi)瘤變的病理分級呈正相關(guān)。
[Abstract]:Aim to compare the expression of nuclein in cervical squamous cell carcinoma, cervical intraepithelial neoplasia and normal cervical tissue, and to explore the role of nuclein expression in the carcinogenesis and development of cervical squamous cell carcinoma. Methods the expression of nuclein was detected by immunohistochemistry in 50 cases of cervical squamous cell carcinoma, 65 cases of cervical intraepithelial neoplasia and normal cervical tissues. The relationship between the expression of nuclein and the pathological grade of cervical squamous cell carcinoma and cervical intraepithelial neoplasia was analyzed. Results the positive expression rate of nuclein in cervical squamous cell carcinoma was significantly higher than that in cervical intraepithelial neoplasia and normal cervical tissue. The positive expression rate of nuclein in cervical intraepithelial neoplasia was significantly higher than that in normal cervical tissue. The expression of nuclein in cervical squamous cell carcinoma (7.6 鹵0.3) was significantly higher than that in cervical intraepithelial neoplasia (6.1 鹵0.2) and normal cervical tissue (3.0 鹵0.2), P 0.01. The change of cervical intraepithelial neoplasia was significantly higher than that of normal cervical tissue, P0.01. The expression of nuclein in moderately-poorly differentiated cervical squamous cell carcinoma (7.9 鹵0.1) was significantly higher than that in well-differentiated cervical squamous cell carcinoma (7.0 鹵0.2). High grade intraepithelial neoplasia (6.0 鹵0.1) was significantly higher than that of low grade intraepithelial neoplasia (4.0 鹵0.2), P 0.01. Conclusion the expression of nuclein is increased in cervical squamous cell carcinoma and cervical intraepithelial neoplasia, and the expression of nuclein is positively correlated with the pathological grade of cervical squamous cell carcinoma and cervical intraepithelial neoplasia.
【作者單位】： 湘南學(xué)院病理學(xué)教研室//附屬醫(yī)院病理科;
【分類號】：R737.33

【參考文獻】

相關(guān)期刊論文 前1條

1 蒙國照;丁宇;高雙全;李靜;范麗萍;;核仁素的表達定位和定量與前列腺癌演變的關(guān)系[J];臨床與實驗病理學(xué)雜志;2011年12期

【共引文獻】

相關(guān)期刊論文 前2條

1 李東梅;洪承皎;張保國;;AS1411輻射增敏機理的研究[J];輻射研究與輻射工藝學(xué)報;2014年03期

2 楊香山;范開席;李成軍;李愛萍;張晶;馮曼;;膜表面核仁素參與表皮生長因子受體信號啟動的研究[J];中國普外基礎(chǔ)與臨床雜志;2013年10期

【二級參考文獻】

相關(guān)期刊論文 前4條

1 吳蓓;王萬春;黎志宏;;核仁素表達下調(diào)對順鉑誘導(dǎo)人骨肉瘤細胞株SaOS-2增殖抑制和凋亡的影響[J];中南大學(xué)學(xué)報(醫(yī)學(xué)版);2012年01期

2 王慷慨;方立;蔣碧梅;鄧恭華;涂自智;陳廣文;肖獻忠;;核仁素在不同細胞膜表面的表達[J];中國動脈硬化雜志;2007年01期

3 郭鈺英;蒙國照;錢成明;;核仁素和Ki-67在口腔鱗癌與癌前病變中的表達及意義[J];口腔醫(yī)學(xué)研究;2011年11期

4 譚桂煌;曾龍武;侯素平;張慶麗;謝海龍;;siRNA抑制cortactin基因表達對Hep-2細胞增殖和侵襲的影響[J];中國癌癥雜志;2010年05期

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