【摘要】：目的研究孕婦尿中毒死蜱(chlorpyrifos,CPF)暴露水平及其影響因素,為評估宮內CPF暴露對兒童健康影響提供科學依據(jù)。方法于2009年6月—2010年1月選取江蘇省某縣1 100名孕婦為研究對象,采集孕婦尿樣并完成調查問卷,以氣相色譜-串聯(lián)質譜法(GC-MS/MS)檢測尿中CPF代謝物3,5,6-三氯-2-吡啶醇(3,5,6-trichloro-2-pyridinol,TCPy)濃度,估算孕婦CPF的每日攝入量(absorbed daily dose,ADD)并分析其影響因素。結果孕婦尿中TCPy檢出率為100%,TCPy肌酐校正濃度范圍為0.14~135.44μg/g Cr,中位值為6.96μg/g Cr,高于國外研究報道水平;估算的ADD中位值為0.31μg/(kg·d),低于農藥殘留聯(lián)席會議(Joint Meeting of Pesticide Residues,JMPR)制定的每日允許攝入量[0.01 mg/(kg·d)],但有51.4%的孕婦ADD值超過了美國環(huán)保局(Environmental Protection Agency,EPA)制定的慢性參考劑量[chronic reference doses,0.3μg/(kg·d)]。統(tǒng)計分析顯示孕婦體內CPF負荷水平與工作類型、家庭收入、居住地類型和季節(jié)等因素有關。結論該地區(qū)孕婦普遍暴露于CPF農藥,半數(shù)以上孕婦ADD水平高于EPA制定的慢性參考劑量,提示母嬰有農藥暴露的潛在健康風險。孕婦工作類型、家庭收入、居住地環(huán)境和季節(jié)是影響孕婦CPF暴露水平的主要因素。
[Abstract]:Objective to study the levels of urinary chlorpyrifos (chlorpyrifos,CPF) exposure in pregnant women and its influencing factors in order to provide a scientific basis for assessing the effects of intrauterine CPF exposure on children's health. Methods from June 2009 to January 2010, 1 100 pregnant women in a county of Jiangsu Province were selected as subjects. Urine samples of pregnant women were collected and questionnaires were completed. Urine CPF metabolites 3,5,5 were detected by gas chromatography-tandem mass spectrometry (GC-MS/MS). The concentration of 6-trichloro-2-pyridinol (3, 5, 6-trichloro-2-pyridinol, TCPy) was used to estimate the daily intake of CPF in pregnant women (absorbed daily dose,ADD) and its influencing factors were analyzed. Results the detection rate of TCPy in urine of pregnant women was 100%. The median concentration of TCPy creatinine was 0.14 ~ 135.44 渭 g / g Cr,. The median value was 6.96 渭 g / g Cr, which was higher than that reported by foreign studies. The estimated median value of ADD was 0.31 渭 g / (kg 路d), lower than the ADI set by the Joint meeting on Pesticide residues (Joint Meeting of Pesticide Residues,JMPR) [0.01 mg/ (kg 路d)], However, 51.4% of pregnant women with ADD exceeded the chronic reference dose [chronic reference doses, 0.3 渭 g / (kg 路d)] set by the U.S. Environmental Protection Agency (Environmental Protection Agency,EPA). Statistical analysis showed that the level of CPF load in pregnant women was related to the type of work, family income, residence type and season. Conclusion pregnant women in this area are generally exposed to CPF pesticides, and more than half of pregnant women have higher levels of ADD than the chronic reference dose established by EPA, suggesting that there is a potential health risk for maternal and infant exposure to pesticides. The type of work, family income, living environment and season of pregnant women were the main factors influencing the level of CPF exposure of pregnant women.
【作者單位】： 復旦大學公共衛(wèi)生學院國民健康社會風險預警協(xié)同創(chuàng)新中心教育部公共衛(wèi)生安全重點實驗室;上海市疾病預防控制中心;
【基金】：上海市自然科學基金(11ZR1402200)
【分類號】：R446.12;R714.2
，

本文編號：2455003