【摘要】：目的探討改良超長方案對多囊卵巢綜合癥(PCOS)不孕患者子宮內(nèi)膜容受性的影響。方法選擇PCOS不孕患者100例,根據(jù)隨機(jī)數(shù)字表法分為改良組和對照組,每組50例。改良組給予改良超長方案,對照組給予標(biāo)準(zhǔn)長效長方案。經(jīng)陰道超聲檢查觀察排卵情況及治療前后子宮內(nèi)膜變化情況;著床窗口期對內(nèi)膜間質(zhì)和腺體分別進(jìn)行整合素αv、β3及雌激素受體(ER)、孕激素受體(PR)、雄激素受體(AR)的免疫組織化學(xué)染色;治療后對治療總有效率進(jìn)行Salle評分。結(jié)果改良組排卵周期數(shù)明顯多于對照組,排卵率明顯高于對照組(P0.01);改良組、對照組治療后子宮內(nèi)膜厚度均較治療前明顯變厚(P0.01),改良組治療后子宮內(nèi)膜厚度明顯厚于對照組(P0.01)。各組治療后內(nèi)膜血流量均有增加趨勢,改良組治療后內(nèi)膜血流量高于對照組(P0.05)。改良組治療后Salle評分明顯低于對照組(P0.01)。結(jié)論改良超長方案可有效提高PCOS患者排卵率、改善子宮內(nèi)膜容受性,值得臨床推廣。
[Abstract]:Objective to investigate the effect of modified ultra-long regimen on endometrial receptivity in (PCOS) infertility patients with polycystic ovary syndrome (PCOS). Methods A total of 100 PCOS infertile patients were divided into two groups according to the method of random number table: improved group and control group, 50 cases in each group. The improved group was given the modified long-term regimen, and the control group was given the standard long-term plan. Transvaginal ultrasound was used to observe ovulation and endometrial changes before and after treatment. Immunohistochemical staining of integrin 偽 v, 尾 3 and estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) were performed in endometrial interstitial and glandular stroma during implantation window, and the total effective rate was evaluated by Salle after treatment. Results the number of ovulation cycles in the improved group was significantly higher than that in the control group, and the ovulation rate was significantly higher than that in the control group (P0.01). In the improved group, the endometrial thickness in the control group was significantly thicker than that in the control group after treatment (P0.01), and the endometrial thickness in the modified group was significantly thicker than that in the control group after treatment (P0.01). After treatment, the intimal blood flow in the improved group was higher than that in the control group (P0.05). After treatment, the Salle score in the improved group was significantly lower than that in the control group (P0.01). Conclusion the modified super-long regimen can effectively improve ovulation rate and endometrial receptivity in patients with PCOS, which is worthy of clinical application.
【作者單位】： 陜西省漢中市三二零一醫(yī)院婦產(chǎn)科;
【分類號】：R711.75;R711.6

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