【摘要】：目的探討25羥維生素D[25(OH)D3]與妊娠期代謝性疾病綜合征(GMS)的相關(guān)性。方法選取2015年1月至2016年1月廣東省婦幼保健院婦產(chǎn)科收集的100例確診為妊娠期代謝綜合征婦女作為GSM組,另選100例正常妊娠婦女作為對(duì)照組,檢測(cè)兩組婦女的血25羥維生素D及相關(guān)代謝指標(biāo),并分析其相關(guān)性。結(jié)果 GMS組的年齡、孕次、分娩次數(shù)、高密度脂蛋白(HDL-C)水平與對(duì)照組差異均無統(tǒng)計(jì)學(xué)意義(t值分別為0.508,1.010,1.179,1.026,P0.05),GMS組的體質(zhì)量指數(shù)(BMI)、總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)、收縮壓(SBP)、舒張壓(DBP)、空腹血糖(FPG)、糖化血紅蛋白(Hb A1c)、游離脂肪酸(FFA)水平均顯著高于對(duì)照組(t值分別為9.284、5.572、4.480、3.192、6.184、4.317、8.689、9.360、3.070,均P0.05),GM S組的25(OH)D3水平顯著低于對(duì)照組(t=16.856,P0.05);多因素分析法采用Logistic回歸進(jìn)入法進(jìn)行分析,結(jié)果顯示:孕期BMI、糖化血紅蛋白與妊娠婦女并發(fā)GMS具有正相關(guān)關(guān)系,而25(OH)D3水平與妊娠婦女并發(fā)GMS具有負(fù)相關(guān)關(guān)系(OR值分別為1.797、1.338、-1.619,均P0.05)。結(jié)論 25(OH)D3缺乏是妊娠期代謝性疾病綜合征的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the relationship between 25-hydroxyvitamin D (25-(OH) D _ 3) and metabolic disorder syndrome (GMS) in pregnancy. Methods from January 2015 to January 2016, a total of 100 women diagnosed as metabolic syndrome during pregnancy were selected as GSM group and 100 normal pregnant women as control group, which were collected from gynaecology and obstetrics department of Guangdong Maternal and Child Health Care Hospital from January 2015 to January 2016. Serum 25-hydroxyvitamin D and related metabolic indexes were measured in two groups of women, and their correlation was analyzed. Results there was no significant difference in age, pregnancy, delivery times, and high density lipoprotein (HDL-C) levels between GMS group and control group (t = 0.508, 1.010, 1.179, 1.026, P 0.05). The body mass index (BMI),) of), GMS group was significantly higher than that of control group (t = 0.508,1.010,1.179 and 1.026, respectively). Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose, (FPG), glycosylated hemoglobin (Hb A1c), The levels of free fatty acid (FFA) in the), GM S group were significantly higher than those in the control group (t = 9.284, 5.572, 4.480, 3.192, 6.184, 4.317, 8.689,9.360, 3.070, P 0.05), the level of 25 (OH) D3 in the), GM S group was significantly lower than that in the control group (t = 16.856, P < 0.05). (P 0.05); Multivariate analysis was carried out by Logistic regression method. The results showed that there was a positive correlation between BMI, glycosylated hemoglobin and pregnant women complicated with GMS. There was a negative correlation between 25 (OH) D3 level and GMS in pregnant women (OR = 1.797, 1.338, respectively, P 0.05). Conclusion 25 (OH) D3 deficiency is an independent risk factor for metabolic disease syndrome in pregnancy.
【作者單位】： 廣東省婦幼保健院婦產(chǎn)科;
【分類號(hào)】：R714.256

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