發(fā)布時(shí)間：2019-03-29 13:05

【摘要】：目的:基于Meta分析結(jié)果,運(yùn)用綜合受試者工作特征曲線技術(shù)(summary receiver operating characteristic,SROC)5種技術(shù)方法評價(jià)妊娠肝內(nèi)膽汁淤積癥(intrahepatic cholestasis of pregnancy,ICP)中總膽汁酸(total bile acid,TBA)的診斷價(jià)值。方法:檢索中文數(shù)據(jù)庫:中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBM)、萬方、CNKI;英文數(shù)據(jù)庫:Pub Med,High Wire,Ovid,the Cochrane Library,Google scholar research。文獻(xiàn)搜索的截至日期為2015年5月。對所納入的文獻(xiàn)進(jìn)行質(zhì)量評價(jià)和數(shù)據(jù)提取后,利用Meta分析所收集的TBA的靈敏度、特異度等數(shù)據(jù)信息,運(yùn)用雙變量隨機(jī)效應(yīng)模型的SROC 5種方法:ηonξ、ξonη、D on S、RG(Rutter and Gatsonis)、主軸法,應(yīng)用SAS的MIXED和NLMIXED過程步得到參數(shù),建立5種模型,評價(jià)TBA對ICP的診斷價(jià)值。結(jié)果:通過Meta分析檢索步驟,最終納入6篇文獻(xiàn),根據(jù)5種方法計(jì)算出診斷評價(jià)結(jié)果曲線下面積(area under curve,AUC)值顯示:ηonξ:0.711,ξonη:0.448;D on S:0.730;RG:0.801;主軸法:0.703,提示TBA的診斷準(zhǔn)確性較高,而5種技術(shù)方法的AUC和SROC圖形結(jié)果顯示:RG評價(jià)TBA準(zhǔn)確性的效果較其他方法更好。結(jié)論:TBA診斷ICP的準(zhǔn)確性較好,但RG的效果評價(jià)需進(jìn)一步驗(yàn)證。
[Abstract]:Aim: to evaluate the diagnostic value of total bile acid (total bile acid,TBA) in intrahepatic cholestasis of pregnancy (intrahepatic cholestasis of pregnancy,ICP) by five techniques based on the results of Meta analysis and comprehensive receiver operating characteristic curve (summary receiver operating characteristic,SROC) technique. Methods: Chinese database: (CBM), Wanfang, CNKI; English database: Pub Med,High Wire,Ovid,the Cochrane Library,Google scholar research. The deadline for literature search is May 2015. After the quality evaluation and data extraction of the included documents, the sensitivity and specificity of the collected TBA were analyzed by Meta, and five methods of SROC of the bivariate random effect model were used: 畏 on 尉, 尉 on 畏, D on S, RG (Rutter and Gatsonis),. Using SAS's MIXED and NLMIXED process steps to get parameters, five models were established to evaluate the diagnostic value of TBA for ICP. Results: by means of Meta analysis and retrieval steps, six literatures were included. According to five methods, the area (area under curve,AUC under the curve of diagnostic evaluation results was calculated. The results showed that 畏 on 尉: 0.711, 尉 on 畏: 0.448 D on S = 0.730; RG:0.801; spindle method: 0.703, which indicated that the diagnostic accuracy of TBA was higher than that of other methods. The results of AUC and SROC showed that RG was more effective than other methods in evaluating the accuracy of TBA. The results of AUC and SROC showed that RG was more effective than other methods in evaluating the accuracy of TBA. Conclusion: the accuracy of TBA in the diagnosis of ICP is good, but the evaluation of the effect of RG should be further verified.
【作者單位】： 重慶醫(yī)科大學(xué)公共衛(wèi)生與管理學(xué)院衛(wèi)生統(tǒng)計(jì)與信息管理教研室;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(編號:81373103) 重慶市自然科學(xué)基金資助項(xiàng)目(編號:cstc2013jcyj A0068)
【分類號】：R714.25;R-03

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 張堅(jiān);血清總膽汁酸的測定在妊娠肝內(nèi)膽汁瘀積癥中的診斷意義[J];實(shí)用婦產(chǎn)科雜志;2000年06期

2 陳慧;周媛;鄧東銳;郝海燕;黨靜;李靜;;Intrahepatic Cholestasis of Pregnancy: Biochemical Predictors of Adverse Perinatal Outcomes[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2013年03期

3 蔣映雪;邵勇;;應(yīng)用ROC曲線評價(jià)肝功能指標(biāo)在妊娠肝內(nèi)膽汁淤積癥診斷中的價(jià)值[J];現(xiàn)代醫(yī)藥衛(wèi)生;2012年10期

4 孫迎軍;;生化指標(biāo)檢測對妊娠期肝內(nèi)膽汁淤積癥的臨床意義[J];中國實(shí)用醫(yī)藥;2011年03期

5 鄔蘭;張永;曾憲濤;;QUADAS-2在診斷準(zhǔn)確性研究的質(zhì)量評價(jià)工具中的應(yīng)用[J];湖北醫(yī)藥學(xué)院學(xué)報(bào);2013年03期

6 劉文華;吳家利;楊揚(yáng);宋婷婷;章順悅;陳遠(yuǎn)方;尹平;;多變量隨機(jī)效應(yīng)模型在診斷試驗(yàn)Meta分析中的應(yīng)用與SAS實(shí)現(xiàn)[J];中國循證醫(yī)學(xué)雜志;2012年02期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 邱翠華;朱薛艷;;中藥對甲氨蝶呤治療未破裂型異位妊娠療效的影響[J];中醫(yī)藥臨床雜志;2006年02期

2 葉紅娟;;自擬活血解毒湯保留灌腸治療慢性盆腔炎84例[J];中醫(yī)藥臨床雜志;2006年06期

3 張菁;呂秀花;韓云鵬;;益氣固沖湯治療更年期功能失調(diào)性子宮出血46例[J];中醫(yī)藥臨床雜志;2007年01期

4 李，

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