【摘要】：目的:探討胚胎反復(fù)著床失敗(RIF)后凍融周期囊胚移植時使用縮宮素受體拮抗劑阿托西班對妊娠結(jié)局的影響。方法:回顧性分析2014年1月到2015年12月RIF,再次行凍融胚胎囊胚移植(bTET)的262例患者的臨床資料,根據(jù)FET日是否使用阿托西班分為觀察組和對照組,觀察組(94例)于移植前0.5 h單劑量靜脈推注小劑量阿托西班(6.75 mg/0.9 m L),對照組(168例)未使用阿托西班。分析比較兩組間的臨床妊娠率、胚胎著床率、多胎妊娠率、自然流產(chǎn)率、異位妊娠率及活產(chǎn)率。結(jié)果:觀察組臨床妊娠率(57.41%)、胚胎著床率(38.41%)、活產(chǎn)率(46.81%)均顯著高于對照組(分別為41.12%、28.32%、33.93%),差異有統(tǒng)計學(xué)意義(P0.05);觀察組自然流產(chǎn)率(14.82%)稍高于對照組(13.04%),多胎妊娠率(16.67%)和宮外孕率(3.70%)均稍低于對照組(分別為17.39%、5.79%),但差異均無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:RIF患者FET日在囊胚移植前給予小劑量阿托西班預(yù)處理可明顯改善臨床妊娠結(jié)局。
[Abstract]:Aim: to investigate the effect of oxytocin receptor antagonist atoxipan on pregnancy outcome in frozen-thawed blastocyst transplantation after repeated implantation failure of (RIF). Methods: from January 2014 to December 2015, a retrospective analysis was made on the clinical data of 262 patients who underwent frozen-thawed blastocyst transfer (bTET) with RIF, again. The patients were divided into observation group and control group according to whether Atosiban was used on FET day or not. In observation group (n = 94), low dose atroxoban was injected intravenously 0.5 h before transplantation (6.75 mg/0.9 m L), control group, n = 168). The clinical pregnancy rate, embryo implantation rate, multiple pregnancy rate, spontaneous abortion rate, ectopic pregnancy rate and live rate were analyzed and compared between the two groups. Results: the clinical pregnancy rate (57.41%), embryo implantation rate (38.41%) and live birth rate (46.81%) in the observation group were significantly higher than those in the control group (41.12%, 28.32%, 33.93%, respectively). The difference was statistically significant (P0.05); The spontaneous abortion rate (14.82%) in the observation group was slightly higher than that in the control group (13.04%), and the multiple pregnancy rate (16.67%) and the extrauterine pregnancy rate (3.70%) in the observation group were slightly lower than those in the control group (17.39% and 5.79%, respectively). But the difference was not statistically significant (P0.05). Conclusion: low-dose atroxoban pretreatment before blastocyst transplantation can significantly improve the outcome of pregnancy in patients with RIF.
【作者單位】： 湖北省婦幼保健院生殖醫(yī)學(xué)中心;
【分類號】：R714.8

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