【摘要】：目的分析體外受精-胚胎培養(yǎng)技術(shù)中胚胎在體外和體內(nèi)發(fā)育速度與性別的關(guān)系。方法回顧性分析經(jīng)輔助生殖治療成功妊娠并獲活產(chǎn)嬰兒的病例資料4 062例,新生嬰兒總數(shù)為5398例。根據(jù)移植胚胎在體外培養(yǎng)時間長短分成第2天移植組(D2)、第3天移植組(D3)、第4天移植組(D4)、第5、6天移植組(D5~6),比較分析胚胎體外培養(yǎng)時間和發(fā)育速度與出生嬰兒性別的關(guān)系。同時分析比較同期637對不同性別雙胎妊娠出生嬰兒體重差異。結(jié)果所有活產(chǎn)新生兒中男嬰2 908個,女嬰2 490個,男嬰比例為53.7%,且隨著移植胚胎在體外培養(yǎng)時間的延長,活產(chǎn)男嬰的比例逐漸升高(50.7%、53.5%、53.0%、56.8%),但各組間差異無統(tǒng)計學(xué)意義(P=0.424)。同期出生的637對不同性別雙胎妊娠新生兒中男嬰體重均數(shù)為(2 426±475)g,顯著高于女嬰體重(2 356±865)g(P=0.035)。結(jié)論隨著移植胚胎在體外培養(yǎng)時間的延長,活產(chǎn)男嬰的比例逐漸升高;此外不同性別胚胎在體內(nèi)的發(fā)育速度也有不同,男性新生兒體重顯著高于女性新生兒體重。
[Abstract]:Objective to analyze the relationship between in vitro and in vivo development rate and sex of embryos in vitro fertilization and embryo culture. Methods the data of 4 062 cases of successful pregnancy and live delivery after assisted reproductive therapy were analyzed retrospectively. The total number of newborn infants was 5398. According to how long the embryo was cultured in vitro, they were divided into 4 groups: the second day group (D2), the 3rd day group (D3), the 4th day group (D4), and the 5th and 6th day group (D5N6). To compare and analyze the relationship between in vitro culture time and development speed of embryo and the sex of born baby. At the same time, the difference of birth weight of 637 pairs of twins in the same period was analyzed. Results among all the live births, 2 908 were male infants and 2 490 female infants. The ratio of male infants was 53.7. With the extension of embryo transfer in vitro, the proportion of male infants increased gradually (50.7% 53.5%). 56.8%, but there was no significant difference among the three groups (P < 0. 424). The mean body weight of the 637 pairs of twins of the same period was (2 426 鹵475) g, which was significantly higher than that of the female (2 356 鹵865) g (P0. 035). Conclusion with the prolongation of embryo transfer in vitro, the proportion of male infants born alive increases gradually, and the growth rate of embryos of different sexes is different in vivo, and the weight of male newborns is significantly higher than that of females.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第三醫(yī)院生殖醫(yī)學(xué)中心廣東省生殖醫(yī)學(xué)重點實驗室;
【基金】：廣東省教育廳省級重大項目(自然科學(xué)類)(編號:2014KZDXM047)
【分類號】：R714.8
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本文編號：2428641