【摘要】：目的:測(cè)定含銅宮內(nèi)節(jié)育器(CuIUD)中吲哚美辛(IMC)在體外模擬宮腔液中的釋放規(guī)律。方法:以體外模擬宮腔液作為提取介質(zhì),在37±0.5℃條件下靜態(tài)釋放IMC,然后通過高效液相色譜(HPLC)檢測(cè)IMC的釋放量。結(jié)果:IMC釋放試驗(yàn)的前期釋放量有較大(2.2~2.5 mg)的藥物突釋現(xiàn)象,釋放率占載藥量的10%,中期IMC的日均釋放量逐漸變得緩慢,后期IMC的日均釋放量趨于穩(wěn)定。整個(gè)周期的釋放量為7~12 mg,釋放率占載藥量的36%~49%。結(jié)論:建立了HPLC測(cè)定IMC在模擬宮腔液釋放量的方法,且IMC體外累積釋放率呈冪函數(shù)釋放規(guī)律,每日釋放量呈逐日下降趨勢(shì)。
[Abstract]:Aim: to determine the release of indomethacin (IMC) from copper-containing intrauterine device (CuIUD) in simulated uterine fluid in vitro. Methods: in vitro simulated uterine fluid was used as the extraction medium. IMC, was released statically at 37 鹵0.5 鈩，

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