【摘要】：目的探討胰島素抵抗(IR)對多囊卵巢綜合征(PCOS)患者血清性激素水平的影響及機制。方法研究對象為同期收治的64例POCS患者(POCS組),其中伴IR(IR指數(shù)1.95)48例、不伴IR 18例;同期40例正常育齡期健康體檢者為正常組。采用免疫發(fā)光法檢測兩組血清性激素[雌二醇(E2)、睪酮(T)、脫氫表雄酮(DHEA)]水平;分析POCS組性激素水平與IR指數(shù)的相關性。結果 PCOS組血清E2、T、DHEA水平均高于對照組(P均0.05);POCS伴IR者血清T、DHEA水平高于不伴IR者(P均0.05);PCOS患者血清T、DHEA水平與IR間呈顯著正相關(r=0.574、0.428,P均0.05),而血清E2水平與IR無相關性。結論血清性激素水平可作為新的檢測指標提高PCOS伴IR的診斷水平。
[Abstract]:Objective to investigate the effect and mechanism of insulin resistance (IR) on serum sex hormone levels in patients with polycystic ovary syndrome (PCOS). Methods Sixty-four patients with POCS (POCS group) were treated in the same period, including 48 patients with IR (IR index (1.95), 18 patients without IR, and 40 healthy persons with normal reproductive age. The serum levels of estradiol (E2) and testosterone (T), dehydroepiandrosterone (DHEA) were measured by immunoluminescent method, and the correlation between sex hormone level and IR index in POCS group was analyzed. Results the serum levels of PCOS in patients with PCOS were significantly higher than those in the controls (P 0.05). The levels of serum THEA in patients with IR were significantly higher than those in patients without IR (P 0.05). There was a significant positive correlation between serum Tet DHEA and IR in PCOS patients (r = 0.574, 0.428, P 0.05), but no correlation was found between serum E _ 2 and IR. Conclusion Serum sex hormone level can be used as a new index to improve the diagnostic level of PCOS with IR.
【作者單位】： 汕頭大學醫(yī)學院第一附屬醫(yī)院;
【基金】：廣東省汕頭市醫(yī)療科技計劃項目(汕府科[2012]113號)
【分類號】：R711.75

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