【摘要】：目的探討良性轉(zhuǎn)移性平滑肌瘤(BML)的臨床病理特征、診斷與鑒別診斷。方法回顧性分析6例BML患者的臨床資料和組織病理學(xué)特點(diǎn),對(duì)腫瘤組織進(jìn)行光鏡觀察及免疫組化研究。結(jié)果6例BML均為女性,平均50.2歲。5例子宮平滑肌瘤術(shù)后7～18年發(fā)生轉(zhuǎn)移,其中1例同時(shí)發(fā)現(xiàn)原發(fā)灶和轉(zhuǎn)移灶。肺轉(zhuǎn)移5例,其中1例伴有腰椎轉(zhuǎn)移,另1例為腹腔淋巴結(jié)轉(zhuǎn)移,復(fù)查子宮手術(shù)后病理切片證實(shí)為良性平滑肌瘤,肺、淋巴結(jié)及腰椎腫瘤組織形態(tài)類似于子宮平滑肌瘤,細(xì)胞無異型,未找到核分裂象。免疫組化染色證實(shí)為平滑肌源性,雌、孕激素受體(+)。結(jié)論BML是一種罕見的發(fā)生于有子宮平滑肌瘤手術(shù)史的女性,肺是主要轉(zhuǎn)移部位,激素依賴性。該病變病程緩慢,手術(shù)切除是主要的治療手段。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of benign metastatic leiomyoma (BML). Methods the clinical data and histopathological features of 6 patients with BML were retrospectively analyzed. Results all 6 cases of BML were female with an average age of 50.2 years. 5 cases of uterine leiomyoma had metastasis from 7 to 18 years after operation. There were 5 cases of lung metastasis, including 1 case with lumbar vertebra metastasis and 1 case with abdominal lymph node metastasis. The pathological section after uterine operation confirmed benign leiomyoma. The histology of lung, lymph node and lumbar vertebrae tumor was similar to that of uterine leiomyoma. No abnormal cells were found and mitotic signs were not found. Immunohistochemical staining confirmed smooth muscle derived, estrogen and progesterone receptor (). Conclusion BML is a rare occurrence in women with a history of uterine leiomyoma. The lung is the main metastatic site and hormone dependent. The course of the disease is slow, surgical resection is the main treatment.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院腫瘤醫(yī)院腫瘤研究所病理科;
【分類號(hào)】：R737.33

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本文編號(hào)：2351008