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卵巢子宮內(nèi)膜異位癥181例臨床分析

發(fā)布時間:2018-11-19 20:34
【摘要】:目的:探討卵巢子宮內(nèi)膜異位癥復(fù)發(fā)的影響因素 方法:回顧性分析2009年1月-2012年12月經(jīng)大連醫(yī)科大學(xué)附屬第一醫(yī)院手術(shù)治療的181例卵巢子宮內(nèi)膜異位癥患者臨床資料,采用logistic回歸分析影響術(shù)后復(fù)發(fā)的因素。 結(jié)果:(1)181例患者的平均年齡為34.7±1.8歲,,76.8%的患者年齡分布于21-40歲。 (2)181例患者中,113例(62.4%)月經(jīng)改變,90例(49.7%)痛經(jīng),78例(43.1%)慢性盆腔痛,81例(44.8%)例不孕,表現(xiàn)性交痛有3例(1.7%)。181例病例常見臨床表現(xiàn)依次為月經(jīng)改變、痛經(jīng)、不孕、慢性盆腔痛、性交痛。臨床癥狀與臨床分期相關(guān),表現(xiàn)為臨床分期越大,臨床癥狀越復(fù)雜。 (3)Ⅰ期患者CA125陽性2例(25%),Ⅱ期患者CA125陽性3例(21.4%),Ⅲ期患者CA125陽性51例(61.4%),Ⅳ期患者CA125陽性55例(73.3%),CA125陽性率與臨床分期相關(guān),臨床分期越晚,CA125值陽性率越高。 (4)應(yīng)用logistic逐步回歸分析卵巢子宮內(nèi)膜異位癥復(fù)發(fā)的相關(guān)因素,年齡、CA125值、AFS分期、手術(shù)方式均不是影響復(fù)發(fā)的因素;術(shù)后是否用藥可以影響復(fù)發(fā)。 (5)181例患者術(shù)后給予輔助藥物治療102例,復(fù)發(fā)14例,術(shù)后未給予輔助藥物治療79例,復(fù)發(fā)23例,對兩組患者的復(fù)發(fā)率差異進(jìn)行X2檢驗(yàn),有統(tǒng)計學(xué)意義,表明術(shù)后未用藥組復(fù)發(fā)率高于用藥組。 (6)分析術(shù)后應(yīng)用促性腺激素釋放激素激動劑(GnRH-a)、避孕藥、中藥對復(fù)發(fā)率的影響,術(shù)后應(yīng)用GnRH-a治療76例,復(fù)發(fā)8例;口服避孕藥治療19例,復(fù)發(fā)6例;口服中藥治療7例,復(fù)發(fā)0例。對GnRH-a治療組與口服避孕藥組、GnRH-a治療組與口服中藥組、口服避孕藥組與口服中藥組復(fù)發(fā)率差異進(jìn)行X2檢驗(yàn),結(jié)果為,GnRH-a治療組與口服中藥組、口服避孕藥組與口服中藥組治療效果無差異,術(shù)后應(yīng)用GnRH-a治療優(yōu)于口服避孕藥。 結(jié)論:(1)卵巢子宮內(nèi)膜異位癥多分布于21-40歲育齡期婦女。 (2)患者的臨床分期愈高,其臨床表現(xiàn)越復(fù)雜,CA125水平陽性愈高。 (3)術(shù)后輔助用藥可以減少術(shù)后復(fù)發(fā),GnRH-a治療效果優(yōu)于避孕藥。
[Abstract]:Objective: to investigate the factors influencing the recurrence of ovarian endometriosis. Methods: the clinical data of 181 patients with ovarian endometriosis treated by surgery from January 2009 to December 2012 in the first affiliated Hospital of Dalian Medical University were analyzed retrospectively. Logistic regression analysis was used to analyze the risk factors of postoperative recurrence. Results: (1) the average age of 181 patients was 34.7 鹵1.8 years old, and 76.8% of the patients were aged 21-40 years. (2) among 181 patients, 113 (62.4%) had menorrhagia, 90 (49.7%) had dysmenorrhea, 78 (43.1%) had chronic pelvic pain, 81 (44.8%) had infertility. The common clinical manifestations of 181 cases were menstrual change, dysmenorrhea, infertility, chronic pelvic pain and intercourse pain. Clinical symptoms are related to clinical staging, the larger the clinical stage, the more complicated the clinical symptoms. (3) CA125 was positive in 2 cases (25%), CA125 in 3 cases (21.4%) in stage 鈪

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