發(fā)布時間：2018-11-18 20:11

【摘要】：目的:探討短時授精對IVF受精正�；颊唧w外受精-胚胎移植(IVF-ET)治療結局的影響。方法:回顧性分析IVF受精率60%患者的臨床資料,按授精方案分為短時授精組(n=153)和常規(guī)受精組(n=180)。結果:IVF短時授精組和常規(guī)IVF組分別獲卵1 619枚和1 986枚,分別有133名和152名患者接受了新鮮胚胎移植。組間女方年齡、基礎FSH(b FSH)、b LH、b E2、Gn量、h CG注射日FSH水平、h CG注射日E2水平、h CG注射日LH水平、獲卵數(shù)、卵子成熟度及移植日內膜厚度均無統(tǒng)計學差異。IVF短時授精組和常規(guī)IVF組的正常受精率(65.55%vs 67.84%)、正常卵裂率(98.02%vs 96.90%)、胚胎種植率(29.41%vs 27.84%)、臨床妊娠率(44.36%vs 45.39%)、繼續(xù)妊娠率(41.35%vs 42.76%)、流產率(5.45%vs 2.90%)和異位妊娠率(1.82%vs 2.90%)均無統(tǒng)計學差異,但是短時授精組的多原核受精率(14.56%)顯著高于常規(guī)IVF組(6.19%),而短時授精組的優(yōu)質胚胎率(33.51%)高于常規(guī)IVF組(28.99%)。結論:因IVF短時授精可避免常規(guī)IVF完全受精失敗而逐漸在國內廣泛應用,但其遠期影響還有待進一步認識。
[Abstract]:Aim: to investigate the effect of short-time insemination on the outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with normal IVF fertilization. Methods: the clinical data of 60% patients with IVF fertilization rate were retrospectively analyzed. According to the insemination scheme, they were divided into short-time insemination group (nong153) and conventional fertilization group (nt180). Results: 1 619 eggs and 1 986 eggs were obtained in IVF short time insemination group and routine IVF group, and 133 and 152 patients received fresh embryo transfer, respectively. Age of intergroup, basal FSH (b FSH), b LH,b E2Gn dose, FSH level on, h CG injection day, E2 level on, h CG injection day, LH level on, h CG injection day, number of eggs obtained, The normal fertilization rate (65.55%vs 67.84%) and normal cleavage rate (98.02%vs 96.90%) in IVF short-term insemination group and routine IVF group were not significantly different. Embryo implantation rate (29.41%vs 27.84%), clinical pregnancy rate (44.36%vs 45.39%), continuing pregnancy rate (41.35%vs 42.76%), There was no significant difference in abortion rate (5.45%vs 2.90%) and ectopic pregnancy rate (1.82%vs 2.90%), but the rate of multicore fertilization in short-term insemination group (14.56%) was significantly higher than that in conventional IVF group (6.19%). The rate of high quality embryos in short term insemination group (33.51%) was higher than that in conventional IVF group (28.99%). Conclusion: IVF short term insemination can avoid the failure of complete fertilization of conventional IVF, and it is widely used in China, but its long-term effects need to be further understood.
【作者單位】： 北京大學深圳醫(yī)院生殖醫(yī)學科;
【基金】：國家自然科學基金項目(項目批準號:30900817) 深圳市科技計劃項目(項目批準號:201302069,JCYJ201206 18,ZYC201006180435A)
【分類號】：R714.8

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