【摘要】：目的:研究探討卵泡輸出率(Follicular out-put rate,FORT)在預(yù)測和指導(dǎo)行體外授精-胚胎移植(In vitro fertilization and embryo transfer,IVF-ET)技術(shù)的高齡不懷孕婦女助孕結(jié)局中的應(yīng)用價值。方法:回顧性分析了2015年1月到2016年1月在新疆省烏魯木齊市的新疆醫(yī)科大學(xué)第一附屬醫(yī)院婦科生殖助孕中心就診,應(yīng)用了拮抗劑方案行控制性超排卵(Controlled ovarian hyperstimulation,COH)的高齡不孕婦女一共有130人的相關(guān)資料。根據(jù)計算所得FORT值的25%和75%中位數(shù)將所有符合納入要求的目標(biāo)人群分為高(n=33人)、中(n=41人)、低FORT(n=56人)組,比較三組人群間的COH結(jié)果及實(shí)驗(yàn)的一些相關(guān)指標(biāo)。結(jié)果:三組病人在年齡大小、基礎(chǔ)的的激素水平基礎(chǔ)促卵泡激素(bFSH)、基礎(chǔ)促黃體激素(bLH)、促性腺激素(Gn)使用的劑量及月經(jīng)周期第三天直徑大小為3-8mm的卵泡總個數(shù)(Antral follicle count,AFC)等基線的周期資料上沒有統(tǒng)計學(xué)差異(P0.05)。比較三組人群間的排卵前卵泡數(shù)(Premature follicle count,PFC)、獲卵數(shù)、2PN、2PN卵裂數(shù)、可移植胚胎數(shù)、優(yōu)胚數(shù),高、中FORT組均較低FORT組高,差異方面有統(tǒng)計學(xué)意義(P0.05),然而相關(guān)數(shù)據(jù)卻在高FORT組與中FORT組間比較沒有統(tǒng)計學(xué)上的意義(P0.05);就種植率和臨床妊娠率這兩個指標(biāo)比較,三組間沒有統(tǒng)計學(xué)差異(P0.05)。結(jié)論:FORT這一指標(biāo)可以為高齡但不孕的婦女的臨床助孕結(jié)局提供一定的臨床指導(dǎo):高FORT者在促排過成中卵巢對Gn的療效會更好,但是FORT最終是否可以為高齡不孕婦女的助孕結(jié)局提供準(zhǔn)確的預(yù)測價值尚需進(jìn)一步探討研究。
[Abstract]:Objective: to investigate the value of follicular output (Follicular out-put rate,FORT) in predicting and guiding the outcome of pregnancy assistance in elderly non-pregnant women using in vitro insemination and embryo transfer (In vitro fertilization and embryo transfer,IVF-ET) technique. Methods: from January 2015 to January 2016, a retrospective analysis was made at the Gynecological Center for Reproductive Assistance in the first affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province. The controlled hyperovulation (Controlled ovarian hyperstimulation,) was performed with antagonist regimen. COH) has a total of 130 elderly infertile women. According to the median of 25% and 75% of the calculated FORT, all the target groups that meet the inclusion requirements were divided into three groups: high (n = 33), middle (n = 41) and low FORT (n = 56). The results of COH and some related indexes of the experiment were compared among the three groups. Results: three groups of patients in age, size, basic hormone levels, basic follicle stimulating hormone (bFSH), basic luteinizing hormone (bLH),) There was no significant difference in the baseline data between the dosage of gonadotropin (Gn) and the total number of follicles with diameter of 3-8mm on the third day of menstrual cycle (P0.05). The number of pre-ovulation follicles (Premature follicle count,PFC), the number of eggs obtained, the number of cleavage of 2PNN 2PN, the number of transferable embryos, the number of superior embryos, the number of embryos in middle FORT group were higher than those in low FORT group (P0.05). However, there was no statistical significance between the high FORT group and the middle FORT group (P0.05). There was no statistical difference between the three groups on implant rate and clinical pregnancy rate (P0.05). Conclusion: the index of FORT can provide some clinical guidance for the outcome of assisted pregnancy in the elderly but infertile women. The effect of ovarian on Gn in patients with high FORT is better than that in the patients with high FORT. However, whether FORT can provide accurate predictive value for the outcome of assisted pregnancy in elderly infertile women needs further study.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R714.8

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