【摘要】：目的探討不同控制性超促排卵(controlled ovarian hyperstimulation,COH)方案中血清及卵泡液(follicular fluid,FF)中血管內皮生長因子(vascular endothelial growth factor,VEGF)與抑制素B(inhibin B,INHB)及COH結局的相關性。方法應用酶聯(lián)免疫吸附方法分別檢測長方案組(A組,n=38)及非降調節(jié)方案組(B組,n=38)患者血清及FF中VEGF和INHB水平并行相關性分析。結果 1降調節(jié)足夠長時間(≥18 d)時,血清VEGF水平顯著下降,且促性腺激素(Gn)啟動日A組VEGF水平[(81.50±32.59)ng/L]明顯低于B組[(123.64±53.90)ng/L](P0.01)。2 Gn啟動后A、B組血清VEGF水平呈上升趨勢,h CG注射日后A組繼續(xù)上升,而B組先下降后上升;且h CG注射次日A組VEGF水平[(165.69±38.25)ng/L]明顯高于B組[(136.49±39.19)ng/L](P=0.002);A、B組其它時間血清VEGF水平無統(tǒng)計學差異(P0.05)。3 Gn第5日血清VEGF水平與COH結局相關性最好(P0.01)。4 A、B組FF中VEGF水平隨卵泡直徑增大而升高,大、中卵泡VEGF水平無統(tǒng)計學差異(P0.05),但B組小卵泡VEGF水平[(889.86±268.95)ng/L]明顯高于A組[(728.45±291.88)ng/L](P=0.014);且大卵泡VEGF水平與COH結局顯著呈負相關。5 A、B組血清及FF中VEGF水平與INHB呈顯著負相關。結論 COH過程中,血清及大、中卵泡VEGF水平與卵巢反應性及COH結局負相關,并且可能對INHB分泌起抑制作用。
[Abstract]:Objective to investigate the relationship between vascular endothelial growth factor (vascular endothelial growth factor,VEGF) in serum and follicular fluid (follicular fluid,FF) and the outcome of COH in different controlled hyperstimulation of ovulation (controlled ovarian hyperstimulation,COH). Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect the levels of VEGF and INHB in serum and FF of patients with long regimen (group A, nong38) and non-descending regimen (group B, group B), respectively. Results (1) the serum VEGF level decreased significantly after long enough down-regulation (鈮，

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