【摘要】：目的探討異位妊娠患者行輸卵管切除后對于卵巢儲備、卵巢反應(yīng)性和體外受精(IVF)結(jié)局的影響。方法選取行單側(cè)輸卵管切除術(shù)后行體外受精-胚胎移植(IVF-ET)助孕的患者為手術(shù)組(n=85),同期行IVF助孕的未行輸卵管手術(shù)的患者為對照組(n=68)。分析指標(biāo)包括卵巢儲備[抗苗勒氏管激素(AMH)、竇卵泡數(shù)(AFC)、血清基礎(chǔ)性激素水平(FSH、E2、FSH/E2比值)]、卵巢反應(yīng)性以及IVF結(jié)局(Gn總量、Gn天數(shù)、HCG日子宮內(nèi)膜厚度、E2峰值水平、獲卵數(shù)、優(yōu)胚數(shù)及臨床妊娠率)。結(jié)果與對照組相比,手術(shù)組AMH水平下降(P0.05),AFC下降(P0.05),FSH、E2、FSH/E2比值差異均無統(tǒng)計學(xué)意義(均P0.05)。手術(shù)組85名患者,進(jìn)一步對手術(shù)側(cè)與非手術(shù)側(cè)卵巢功能進(jìn)行比較,結(jié)果表明,手術(shù)側(cè)卵巢AFC下降(P0.05),獲卵數(shù)和卵巢體積無統(tǒng)計學(xué)差異(均P0.05)。手術(shù)組與對照組相比,Gn總量、Gn天數(shù)、HCG日子宮內(nèi)膜厚度、E2峰值水平、獲卵數(shù)、優(yōu)胚數(shù)及臨床妊娠率等差異均無統(tǒng)計學(xué)意義(均P0.05)。結(jié)論單側(cè)輸卵管切除術(shù)會導(dǎo)致卵巢儲備下降,但對卵巢反應(yīng)性和IVF結(jié)局無影響。
[Abstract]:Objective to investigate the effects of oviductal resection on ovarian reserve, ovarian reactivity and (IVF) outcome of in vitro fertilization in patients with ectopic pregnancy. Methods the patients who underwent in vitro fertilization and embryo transfer (IVF-ET) after unilateral salpingotomy were selected as the operative group (nm85), and those who were not undergoing the tubal operation with IVF (NN68) were selected as the control group. The indexes included ovarian reserve [(AMH), antral follicle number], ovarian reactivity and IVF outcome (Gn total, Gn days), serum basic sex hormone level (FSH,E2,FSH/E2 ratio) in (AFC),. On the day of HCG, the thickness of endometrium, the peak level of E _ 2, the number of eggs obtained, the number of superior embryos and the clinical pregnancy rate. Results compared with the control group, the level of AMH in the operation group decreased (P0.05), AFC decreased (P0.05), the ratio of FSH,E2,FSH/E2 was not significantly different (P0.05). The ovarian function of the operative side and the non-operative side were further compared in the operation group (85 patients). The results showed that the AFC of the operative side decreased (P0.05), the number of oocytes obtained and the ovarian volume had no statistical difference (P0.05). Compared with the control group, there were no significant differences in total Gn, days of Gn, thickness of endometrium, peak level of E2, number of eggs acquired, number of excellent embryos and clinical pregnancy rate in the operation group (P0.05). Conclusion unilateral salpingotomy can decrease ovarian reserve, but has no effect on ovarian reactivity and IVF outcome.
【作者單位】： 武漢大學(xué)人民醫(yī)院生殖醫(yī)學(xué)中心;
【基金】：湖北省自然科學(xué)基金資助項目(No.2016CFB352) 湖北省衛(wèi)生計生委面上項目(No.WJ2017M011)
【分類號】：R714.8
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本文編號：2317102