【摘要】：目的觀察妊娠期血糖水平與甲狀腺功能的相關(guān)性,探討GDM是否與妊娠期甲狀腺功能異常相關(guān)。方法選取在我院產(chǎn)檢的孕婦514名,分為GDM組與非GDM組。收集妊娠期血清游離甲狀腺激素(FT_4)、促甲狀腺激素(TSH)、甲狀腺過氧化物酶抗體(TpoAb)、75 g OGTT結(jié)果,統(tǒng)計GDM、甲狀腺功能異常的發(fā)病率,比較兩組甲狀腺功能異常的差異,分析FT4、TSH與血糖水平的相關(guān)性。結(jié)果總甲狀腺功能異常發(fā)病率為21.2%,其中臨床甲狀腺功能亢進、亞臨床甲狀腺功能亢進、臨床甲狀腺功能減退、亞臨床甲狀腺功能減退發(fā)病率分別為3.7%、1.9%、0.2%、15.4%,TpoAb陽性率為9.7%,GDM的發(fā)病率為16.3%;GDM組與非GDM組甲狀腺功能異常、TpoAb陽性率比較,差異均無統(tǒng)計學(xué)意義(x~2=0.407、1.051,P=0.523、0.305);妊娠早期TpoAb陽性組與陰性組的GDM發(fā)病率比較,差異有統(tǒng)計學(xué)意義(x~2=6.362,P=0.012),而中晚期則差異無統(tǒng)計學(xué)意義;FT4僅與FPG呈負相關(guān)(r=-0.148,P=0.001),TSH與FPG、1 hPG及2 hPG無相關(guān)性。結(jié)論 GDM與甲狀腺功能異常無相關(guān)性,但妊娠早期TpoAb陽性與GDM發(fā)病可能存在一定的相關(guān)性。
[Abstract]:Objective to investigate the correlation between serum glucose level and thyroid function in pregnancy and whether GDM is correlated with thyroid dysfunction in pregnancy. Methods 514 pregnant women were divided into GDM group and non-GDM group. The results of serum free thyroid hormone (FT_4) and thyroid peroxidase antibody (TpoAb), 75 g OGTT) of thyroid stimulating hormone (TSH),) in pregnancy were collected and the incidence of thyroid dysfunction in GDM, was analyzed. To compare the difference of thyroid dysfunction between the two groups, and analyze the correlation between FT4,TSH and blood glucose level. Results the incidence of total thyroid dysfunction was 21.2. The incidence of clinical hyperthyroidism, subclinical hyperthyroidism, clinical hypothyroidism and subclinical hypothyroidism were 3.7, respectively. The positive rate of TpoAb was 9. 7 and the incidence of GDM was 16. 3. There was no significant difference in the positive rate of thyroid function and TpoAb between the GDM group and the non-GDM group. The incidence of GDM in TpoAb positive group was significantly higher than that in negative group in the first trimester of pregnancy (x2 + 6.362P0. 012), but there was no significant difference in the middle and late stage of pregnancy. There was only negative correlation between FT4 and FPG (r = -0.148), TSH). There was no correlation between), TSH and FPG,1 hPG and 2 hPG. Conclusion there is no correlation between GDM and thyroid dysfunction, but there may be some correlation between TpoAb positive and GDM in early pregnancy.
【作者單位】： 南方醫(yī)科大學(xué)第三附屬醫(yī)院內(nèi)分泌代謝科;
【分類號】：R714.256

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