【摘要】：目的:系統(tǒng)評價胎兒鏡下氣管球囊阻塞術(shù)(FETO)對先天性膈疝(CDH)的治療作用。方法:計算機全面檢索相關(guān)文獻數(shù)據(jù)庫關(guān)于FETO對CDH胎兒治療作用的相關(guān)文獻,檢索英文數(shù)據(jù)庫:Embase、Pub Med、Cochrane Central Register of Controlled Trials(CCRT)、Web of Science、ACP、Medline及Ovid;檢索中文數(shù)據(jù)庫:中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫(CBM)、相關(guān)期刊論文(CNKI)、維普(VIP),萬方;手工檢索相關(guān)會議資料、論文集及學(xué)位論文匯編等。檢索時間為自建庫至2016年9月,檢索內(nèi)容為FETO對CDH胎兒治療作用的隨機對照試驗(randomized controlled trial,RCT)。采用Cochrane系統(tǒng)評價法,對檢索文獻進行質(zhì)量評價和Meta分析,參照PRISMA報告規(guī)范進行報告。其異質(zhì)性采用I~2檢驗,I~2≤50%采用固定效應(yīng)模型,I250%采用隨機效應(yīng)模型;采用Mantel-Haenszel法評估RR和95%CI。結(jié)果:檢索相關(guān)文獻,共兩篇符合本研究納入標(biāo)準,納入受試者孕婦共65例。對納入研究文獻的方法學(xué)質(zhì)量評價結(jié)果顯示納入文獻質(zhì)量適中。FETO組和對照組均未發(fā)生孕產(chǎn)婦死亡和輸血。FETO組與對照組妊娠結(jié)局的Meta分析結(jié)果示:FETO明顯增加早產(chǎn)(RR 1.99,95%CI 1.09~3.61,P=0.02)和未足月胎膜早破(RR 2.41,95%CI 1.26~4.61,P=0.01)的發(fā)病風(fēng)險,而胎盤早剝(RR 3.55,95%CI 0.43~29.42,P=0.24)、母體感染(RR 3.32,95%CI 0.36~30.21,P=0.29)和新生兒存活(RR 2.86,95%CI 0.10~80.82,P=0.54)的發(fā)生率兩組比較差異無統(tǒng)計學(xué)意義。結(jié)論:FETO增加早產(chǎn)和未足月胎膜早破的發(fā)病風(fēng)險,不增加胎盤早剝、母體感染、孕產(chǎn)婦死亡的發(fā)病風(fēng)險,其治療作用有待進一步評估。
[Abstract]:Objective: to evaluate the efficacy of (FETO) in the treatment of congenital diaphragmatic hernia (CDH). Methods: the relevant literatures about the effect of FETO on the fetal treatment of CDH were searched by computer, and the English databases: Embase,Pub Med,Cochrane Central Register of Controlled Trials (CCRT), Web of Science,ACP,Medline and Ovid; were searched. Chinese database: Chinese biomedical literature database (CBM), China periodical full-text database (CNKI), Weipu (VIP), Wanfang; manual retrieval of related conference materials, papers and dissertations, etc. The retrieval time was from the self-built library to September 2016, and the retrieval was a randomized controlled trial (randomized controlled trial,RCT) on the therapeutic effect of FETO on CDH fetus. The Cochrane system evaluation method was used to evaluate the quality and Meta of the retrieval documents, and to report according to the PRISMA report specification. The heterogeneity was tested by Ion2 test, If2 鈮，

本文編號：2311388